14:0 PC-[d58]

14:0 PC-[d58], a deuterated phosphatidylcholine lipid widely utilized in scientific research applications, boasts diverse uses across various disciplines. Here are key applications presented with a high degree of perplexity and burstiness:

Lipidomics Research: Operating as an internal standard in mass spectrometry-driven lipidomics investigations, 14:0 PC-[d58] stands as a linchpin for precise quantification of lipid species within intricate biological samples. This standardization furnishes a steadfast reference point, shedding light on lipid metabolism and diseases intertwined with lipids.

Membrane Studies: Within the realm of biological membranes, 14:0 PC-[d58] emerges as an indispensable tool for probing the nuanced dynamics and organization of lipid bilayers. Researchers introduce deuterated lipids into model membranes to explore the fluidity, phase transitions, and interplay with proteins and other molecules. This knowledge is pivotal for unraveling the structural and functional aspects of cellular membranes.

Pharmacokinetics: In the domain of pharmacokinetic evaluations, 14:0 PC-[d58] serves as a beacon for monitoring the absorption, distribution, and metabolism of lipid-linked drugs. Through the integration of this deuterated lipid into drug formulations, researchers can scrutinize the behavior and interaction of drug-lipid complexes within biological systems using non-invasive methods like MRI. This aids in refining lipid-centric drug delivery systems.

Structural Biology: Harnessing its potential in structural biology, 14:0 PC-[d58] finds application in nuclear magnetic resonance (NMR) inquiries aimed at unraveling the structure and dynamics of membrane proteins. This deuterated lipid amplifies spectral clarity, enabling an intricate analysis of protein-lipid interplay and fostering insights into membrane protein functionality, crucial for drug design and decoding cellular processes.