Isotopes are a fundamental concept in modern science and technology which underpin a diverse range of scientific disciplines from chemistry and molecular biology to environmental science and medicine. Different Neuclidic Ingredients - These variants of elements, possessing different numbers of neutrons and having the same number of protons, offer unique features virtually impossible for valuable research and industrial scientists. BOC Sciences has more than 20 years of experience in isotope drug R D and supply.
Isotope Definition
Isotopes are elements which all have the same number of protons but a different number of neutrons. These slight discrepancies leads to different atomic masses among the isotopes of an element. Isotopes have nearly identical chemical properties, but they have very different physical properties, such as mass and stability. These differences are why isotopes open up unique possibilities in scientific investigations and practical applications.
What are Stable Isotopes?
A number of applications are possible thanks to the stable half-life of the isotope. There are stable isotopes for the first 80 elements on the periodic table which can be used in natural resources, environmental conditions, and biological processes. For example, stable isotopes of hydrogen in water then can be used to identify the age and source of water samples, as applied in isotope hydrology. Nitrogen-15 isotopes are used in agriculture to monitor the plant-uptake of fertilizers, to enhance agricultural practices and increase yields.
Type of Isotopes from BOC Sciences
BOC Sciences offers a comprehensive portfolio of isotope-labeled compounds, catering to various scientific and industrial needs.
In addition, you can get a wide range of labeled isotopes such as deuterium, carbon 13, nitrogen 15, and oxygen 18, as well as a one-stop shop for custom isotopes at BOC Sciences.
Advantages of Isotopic Products from BOC Sciences
Quality and Purity
BOC Sciences is noted for providing the utmost top quality and most pure isotope products. Through a quality control process, our researchers are guaranteed accurate, and consistent data at every stage of their study.
Comprehensive Portfolio
BOC Sciences provides diverse scientific needs by having a wide range of isotope-labeled compounds. Their assays can do scientific exploration, finding out how single cells are experiencing responses to their environment and help generate biologically active compounds.
Innovation and Expertise
With more than 20 years of experience in the industry, BOC Sciences always maintains an innovative spirit to provide a wide range of advanced isotopes. Their experience in the field of isotope chemistry and its utility provides customers with the best possible tools for their work.
Custom Solutions
If your experiment needs, BOC Sciences is your best choose! This flexibility permits scientists to obtain unique labeled compounds that are not commercially available, potentially enabling new areas of research.
Customer Support
Exceptional customer support is part of the package, with BOC Sciences even providing technical assistance and directions on how their isotope products can be used. This support provides researchers the ability for quick and easy access to the equipment needed to accomplish their experiments.
Applications of Isotopes
There are many kinds of stable isotope labeled compounds from BOC Sciences. The applications of stable isotope labeled compounds can range from gases to complex molecules, and their applications have gradually infiltrated into various fields, such as chemistry, molecular biology, improvement of drug efficacy, medical diagnostic reagents, environmental detection, metabolic research, etc.
Isotopes in drug development.
Application in Improving Drug Efficacy
Deuterium-labeled compounds are powerful tools for drug research. For stable isotope deuterium labeling medication, because C-D keys than C-H is more stable, deuterium generation of drugs by metabolic enzymes in organisms (such as cytochrome P450, monoamine oxidase and aldehyde oxidase, etc.) by catalytic metabolic process may be slowed sharply or suspended, affect drug absorption, distribution, metabolism, excretion and other characteristics, so as to bring a lot of clinical benefit, Such as prolonging drug half-life, reducing metabolic burden, reducing drug side effects and so on.
Application in Chemistry
Stable isotope labeled small molecule compounds, including 2H, 13C, 15N labeled small molecule compounds, such as alkanes, alkenes, alcohols, aldehydes, acids, benzene aromatic derivatives and other fine chemicals, can be used as chemical reference for chemical identification, qualitative, quantitative, detection, etc. Stable isotope-labeled chemical solvents can be used for structural, quantitative, and purity analysis of compounds. Solvent labeled with stable isotope can also be used to study chemical reaction pathway, reaction mechanism and reaction kinetics. Stable isotope labeled compounds can also be used to make various types of nuclear magnetic solvents.
Application in Molecular Biology
Molecular biological products prepared by stable isotopes mainly include protective amino acids, labeled media, carbohydrates, RNA/DNA labeled products, labeled proteins, labeled peptides, etc. Stable isotope labeling is an excellent tool in molecular biology, especially for the study of the structure of proteins and peptides.
Application in the Research of Medical Diagnostic Reagents
For the quantitative detection of low content analytes in complex substances, the most accurate method is the combination of isotope dilution and mass spectrometry. For example, stable isotope-labeled compounds, such as 13C-urea and 18O-H2O, can provide quantified isotope-labeled therapeutic drugs for forensic testing.
Application in Environmental Detection
Stable isotope labeled compounds are used as standard fluids for environmental pollutants, including air, water, soil, sediment and food.
Application in Metabolic Research
Stable isotope-labeled substrates for metabolic analysis include amino acids for studying protein and amino acid metabolism, carbohydrates for glucose metabolism, and fatty acids for lipolysis. Stable isotope markers allow researchers to study metabolic pathways in vivo in a safe manner.
FAQ
1:Why isotopes have same chemical properties but different physical properties?
The isotopes of an element will have the same chemical properties as they contain the same number of protons and electrons, which are responsible for the chemical behavior of an element. They are all radioactive, but differ in how unstable they are (have different half-lives), but they can also have various physical properties DUE to their number of neutrons, which affects atomic mass too. This mass difference can cause variations in properties such as density, melting and boiling points, of isotopes of the same element.
2: What are the physical properties of isotopes?
The isotopes differ in atomic mass, stability, radioactivity, and half-life. Neutron-rich isotopes can be radioactive and they display some different chemical behaviors.
3: Why do isotopes exist?
An example is isotopes as they are because they have a different number of neutrons in their nuclei of atoms of the same element. These variations may happen naturally via some nuclear course of or could also be completed by human manipulation. They give more variants of items and serve other functions.
4. How is an isotope formed?
Isotopes are created through nuclear processes in stars and supernovae where atoms are fused or undergo radioactive decay. During these transformations particles can change the number of neutrons in the nuclei of atoms, creating isotopes of the same element. Isotopes are also artificially produced either by nuclear reactions or by particle bombardment.
5. What are examples of isotopes?
Examples of isotopes include:
(1) Hydrogen: Protium (¹H), Deuterium (²H), Tritium (³H)
(2) Carbon: Carbon-12 (¹²C), Carbon-13 (¹³C), Carbon-14 (¹⁴C)
(3) Oxygen: Oxygen-16 (¹⁶O), Oxygen-17 (¹⁷O), Oxygen-18 (¹⁸O)
(4) Uranium: Uranium-235 (²³⁵U), Uranium-238 (²³⁸U)
(5) Chlorine: Chlorine-35 (³⁵Cl), Chlorine-37 (³⁷Cl)
6. What is the isotopic signature?
An isotopic signature is a natural or even man-made ratio of isotopes of a given element in a sample. It is the signature ratio of the source of the sample and can either allow for the source to be identified or for the sample to be traced back to the source or track changes in the sample through space and time. They are extraordinarily valuable in a wide range of fields, together with geology, ecology, archeology, and forensics.
