Stable isotope-labeled compounds are used as environmental pollutant standards for the detection of air, water, soil, sediment and food.
In addition to treating various diseases, isotopes are used for imaging, diagnosis, and newborn screening.
Small molecule compounds labeled with stable isotopes can be used as chemical reference for chemical identification, qualitative, quantitative, detection, etc. Various types of NMR solvents can be used to study the structure, reaction mechanism and reaction kinetics of compounds.
Stable isotope labeling allows researchers to study metabolic pathways in vivo in a safe manner.
BOC Sciences is committed to providing customers with isotope-labeled inhibitors. We offer a complete range of labeled inhibitors standards. All products come with comprehensive analytical data files and are of high chemical purity.
Inhibitors are substances used to block or slow down chemical reactions. Isotope labeled inhibitors refer to replacing one or more atoms in inhibitor molecules with isotopes. Stable isotopes labeled inhibitors are widely used in biomedicine, agriculture and environment.
1. Application in biomedicine
Stable isotope labeled inhibitors are mainly used as tracers to track organisms in vivo and obtain mechanism information for the diagnosis of metabolic related diseases and imaging technology.
By introducing stable isotope labeled inhibitors, we could track the specific metabolic pathways and metabolites in organisms, so as to provide a basis for the study of synthetic biology, disease pathogenesis, drug metabolism and action mechanism.
1.2 imaging technology
Fibroblast activating protein (FAP) is a kind of protein secreted by tumor associated fibroblasts that can promote tumor growth and metastasis. By introducing stable isotope labeled FAP inhibitors, the biological distribution in vivo such as the uptake of animal organs can be observed. So it could be used as a low background imaging agent for the detection of tumors in corresponding target organs.
2. Application in agriculture
In the field of agriculture, stable isotope labeled inhibitors mainly use 15N labeled urea to explore the synergistic mechanism of nitrification inhibitors. Nitrification inhibitors can improve fertilizer utilization and reduce nitrogen loss. Stable isotope labeled nitrification inhibitors could accurately and quantitatively analyze the utilization rate of fertilizer nitrogen, so as to improve the efficiency of vegetable planting system.
3. Application in environment
In the field of environment, stable isotope labeled inhibitors are mainly used for the screening of herbicides. p-Hydroxyphenylpyruvatedioxygenase (HPPD) inhibitor, as a widely used herbicide, can inhibit the production of homogentisic acid (HGA) required for growth in plants. Stable isotope labeled HPPD inhibitors can evaluate the effect of herbicides by recording the signal value of isotopes to determine the generated CO2.