Isotope Labeled Inhibitors
Product List
Small-molecule inhibitors have transformed drug discovery by offering simple yet effective tools to perturb biological pathways. Additionally, these compounds are particularly valuable by virtue of their isotope labeling which provides benefits for both the drug discovery process and development. With experience of more than 20 years in the industry, BOC Sciences is known to supply top-rated isotope labeled inhibitors that strive for results with researchers worldwide. We provide a low volume of labeled inhibitors standards. All data are accompanied by full statistics and the compounds were of high chemical purity. In addition, we also provide custom isotope labeling service for any inhibitors, you can directly provide the Inhibitors to be labeled or make a request such as the type of labeling isotope, the labeling site, and the isotope enrichment.
What is an Inhibitor?
A molecule that binds to a particular protein and decreases its biological activity is an inhibitor. This interaction may happen by the way of enzyme inhibitors, transcription factor inhibitors or ion channel blockers. Small molecule inhibitors are able to express their chemical properties and distribute throughout space very effectively which makes them critical tool molecules in drug discovery, as well as its use therapeutically.
Functions of Inhibitors
Inhibitors merely function by being paired to their target proteins, therefore changing the form or active site of that protein. Such association can be either irreversible or reversible. Irreversible inhibitors make covalent bonds with proteins which means it will permanently inactivate a protein however reversible one binds through non-covalently, these can be dissolved and reactivated the involved protein as needed. There are three types of reversible inhibition that include competitive, noncompetitive and uncompetitive.
What are Isotope Labeled Inhibitors?
Inhibitors are substances used to block or slow down chemical reactions. Isotope labeled inhibitors refer to replacing one or more atoms in inhibitor molecules with isotopes. Stable isotopes labeled inhibitors are widely used in biomedicine, agriculture and environment. Isotope labeled inhibitors are inhibitors tagged with stable isotopes such as carbon-13, nitrogen-15, or deuterium. These labels serve as tracers, allowing precise tracking of the inhibitor within biological systems using techniques like nuclear magnetic resonance (NMR) and mass spectrometry (MS). Isotope labeling provides critical insights into the pharmacokinetics, biodistribution, and mechanism of action of inhibitors.
Our Isotope Labeling Services for Inhibitors
BOC Sciences provides a full range of isotope labeling services to meet your needs for the design and synthesis of inhibitors. With our long synthesis epertise, we are guaranteed to deliver high quality isotopically labeled inhibitors custom tailored for every possible research requirements. We offer isotopes from mg to kg amounts with comprehensive analysis reports.
Choosing Inhibitors for Your Research
Selecting the appropriate inhibitor is crucial for successful research outcomes. Considerations include the specificity of the inhibitor for the target protein, its binding affinity, and its pharmacokinetic properties. It is essential to evaluate the inhibitor's effectiveness in vitro and in vivo, as well as its potential off-target effects.
Choosing Labels for Your Research
The choice of isotope label depends on the research objective. Carbon-13 and nitrogen-15 are commonly used for NMR studies due to their magnetic properties, while deuterium is preferred for studying metabolic pathways and drug interactions. The label should be stable under experimental conditions and should not alter the biological activity of the inhibitor. Commonly used isotopes include:
For more types of inhibitors and isotopic labeling, please contact us directly.
Applications of Isotope Labeled Inhibitors
Application in Biomedicine
Stable isotope labeled inhibitors are mainly used as tracers to track organisms in vivo and obtain mechanism information for the diagnosis of metabolic related diseases and imaging technology.
By introducing stable isotope labeled inhibitors, we could track the specific metabolic pathways and metabolites in organisms, so as to provide a basis for the study of synthetic biology, disease pathogenesis, drug metabolism and action mechanism.
Fibroblast activating protein (FAP) is a kind of protein secreted by tumor associated fibroblasts that can promote tumor growth and metastasis. By introducing stable isotope labeled FAP inhibitors, the biological distribution in vivo such as the uptake of animal organs can be observed. So it could be used as a low background imaging agent for the detection of tumors in corresponding target organs.
Application in Agriculture
In the field of agriculture, stable isotope labeled inhibitors mainly use 15N labeled urea to explore the synergistic mechanism of nitrification inhibitors. Nitrification inhibitors can improve fertilizer utilization and reduce nitrogen loss. Stable isotope labeled nitrification inhibitors could accurately and quantitatively analyze the utilization rate of fertilizer nitrogen, so as to improve the efficiency of vegetable planting system.
Application in Environment
In the field of environment, stable isotope labeled inhibitors are mainly used for the screening of herbicides. p-Hydroxyphenylpyruvatedioxygenase (HPPD) inhibitor, as a widely used herbicide, can inhibit the production of homogentisic acid (HGA) required for growth in plants. Stable isotope labeled HPPD inhibitors can evaluate the effect of herbicides by recording the signal value of isotopes to determine the generated CO2.
Why Choose BOC Sciences for the Synthesis of Your Isotope Labeled Inhibitors?
BOC Sciences stands out as a leader in the synthesis of isotope labeled inhibitors due to our extensive experience, state-of-the-art facilities, and commitment to quality. Our advantages include:
Expertise and Innovation
With over 20 years in the industry, BOC Sciences has accumulated unparalleled expertise in isotope labeling techniques and inhibitor synthesis. Our innovative approaches ensure high-purity products that meet stringent research requirements.
Comprehensive Services
We offer a wide range of isotope labeling services, including custom synthesis, scale-up production, and analytic support. Our services are tailored to meet the specific needs of our clients, ensuring optimal research outcomes.
Quality Assurance
Quality is at the core of our operations. All our isotope labeled inhibitors undergo rigorous quality control, including NMR, HPLC, and MS analysis, to ensure high purity, stability, and consistency.
Customer-Centric Approach
At BOC Sciences, we prioritize customer satisfaction. Our dedicated team of experts works closely with clients to understand their research goals and provide personalized solutions. We offer flexible ordering options, timely delivery, and exceptional customer support.
FAQ
1. What are Serotonin Inhibitors?
Serotonin inhibitors, often referred to as serotonin reuptake inhibitors (SRIs) or selective serotonin reuptake inhibitors (SSRIs), are a class of drugs commonly used to treat depression, anxiety disorders, and certain other mood disorders.
2. What is an ACE Inhibitor?
ACE inhibitors, or angiotensin-converting enzyme inhibitors, are a class of medication used primarily to treat high blood pressure (hypertension) and heart failure.
3. What is a Proton Pump Inhibitor?
Proton pump inhibitors (PPIs) are a class of drugs used to reduce the production of stomach acid. They achieve this by blocking the enzyme system of gastric proton pumps, which are located in the stomach lining.
4. What is a JAK Inhibitor?
JAK inhibitors, or Janus kinase inhibitors, are a type of medication used to treat certain autoimmune diseases and cancers. They work by blocking the activity of one or more of the Janus kinase family of enzymes (JAK1, JAK2, JAK3, TYK2).
5. What are Isotopes in Pharmacy?
Isotopes in pharmacy refer to variants of chemical elements that have the same number of protons but different numbers of neutrons. These isotopes can be stable or radioactive.
