• Custom Isotope Synthesis
• Stable Isotope Labeling Services
• Stable Isotope Analysis Services
• SILAC Analysis Services

Isotopes - variants of chemical elements that differ by their numbers of neutrons - are important for a host of both scientific and industrial research applications. Non-radioactive and stable by nature, stable isotopes are stable physical properties of isotopes so that they can be used for diverse analytical and experimental applications, in contrast to the radioactive isotopes. With more than 20 years of experience in this field and a dedicated team of professionals, BOC Sciences provides a full range of isotopic services for its customers including Custom Synthesis, Stable Isotope Labeling Services, Stable Isotope Testing Services, and SILAC Technical Services These are well-suited to Pharma, Biology, Chemistry, and Environmental Sciences related research and development.

Isotopic Service from BOC Sciences

At BOC Sciences, we offer a comprehensive range of isotopic services designed to meet the diverse needs of our clients. Our expertise in isotopic technology ensures precise and reliable results, fostering advancements in multiple scientific fields.

Custom Synthesis

Custom synthesis of stable isotope-labeled compounds is a core offering at BOC Sciences. We specialize in labeling compounds with deuterium (2H), carbon-13 (13C), nitrogen-15 (15N), and oxygen-18 (18O). These labeled compounds are invaluable in tracing drug metabolism, identifying toxicity causes, and predicting potential toxicity of new compounds. In the pharmaceutical field, stable isotopes are often used as internal standards in NMR and mass spectrometry.

Stable Isotope Labeling Services

Stable isotope labeling is a pivotal application of isotopes, utilized as tracers in chemical reactions. BOC Sciences offers extensive stable isotope labeling services, marking compounds with stable isotopes to study their pathways and mechanisms in biological systems. Our labeling services encompass various compounds, such as amino acids, drugs, and proteins, synthesized to replace corresponding non-labeled compounds. Analytical instruments like mass spectrometry and nuclear magnetic resonance are employed to determine the position and quantity changes of stable isotopes, providing insights into reaction mechanisms.

Stable Isotope Analysis Services

BOC Sciences provides reliable stable isotope testing services, essential for environmental studies, plant growth and metabolism research, and more. Our laboratory is equipped with advanced analytical instruments, including isotope-ratio mass spectrometers (IRMS), element analyzers, gas chromatographs (GC), and mass spectrometers (MS). These instruments enable precise determination of isotope ratios and element content in various samples. Our stable isotope testing services cover:

• Isotopic Composition Analysis
• Isotopic Abundance Determination
• Isotopic Content Determination
• Chemical Purity Analysis
• Impurity Analysis
• Structure Identification

SILAC Technical Services

Stable Isotope Labeling with Amino Acids in Cell Culture (SILAC) is a sophisticated technique offered by BOC Sciences. SILAC involves metabolically labeling cellular proteins with stable isotope-labeled essential amino acids, such as arginine, lysine, and leucine. These labeled amino acids are incorporated into proteins during cell proliferation, enabling the study of protein dynamics and interactions.

Service Workflow

BOC Sciences is committed to providing you with a one-stop custom service, following an optimized and proven process to ensure efficient and quality isotope products.

• Inquiry and Consultation: Customers contact us via phone or email to discuss their needs. A confidentiality agreement is signed.
• Sample Submission: Customers provide samples and relevant information, ensuring samples are uncontaminated and properly handled.
• Quotation and Agreement: Based on customer needs, we provide a quotation and, upon agreement, commence the service.
• Service Execution: Our technical team carries out the requested services, maintaining efficient communication with the client.
• Data Analysis and Reporting: Upon completion, we analyze the data, compile a comprehensive report, and deliver the final product.
• After-Sales Service: We offer continued support to address any post-service issues or questions.

Our Isotope Production Abilities

Our team of scientists and technicians includes experts in. chemistry, biology, and pharmaceuticals. Our isotopic manufacturing capabilities are fully supported. Our team combines decades of experience in isotope technology, relatively, and thereby we are able to perform synthesis, labeling, and evaluation processes with the utmost precision and efficiency. We never stop investing in training and development so that our team can be the most up-to-date experts in the field of isotope science and research.

Advanced Production Facilities

BOC Sciences is well-spending in a variety of production lines that are ready to fabricate with the latest synthesis and analytical technologies across isotopic synthesis, labeling, and testing. Our labs are equipped with the following technology.

• Synthesis Equipment: for custom synthesis of stable isotopelabeled compounds including advanced synthesis reactors, purification systems, analytical instruments.
• Labeling Equipment: instrumentation suitable for stable isotope labeling of amino acids, nucleotides, and other bioactive compounds.
• Test Equipment: State-of-the-art analytical instruments like Isotope-ratio Mass Spectrometers (IRMS), Elemental Analysers, Gas Chromatographs (GC), Mass Spectrometers (MS) for highly accurate and reliable isotopic analysis and testing.

Expert Knowledge and Skilled Personnel

Our isotopic production capabilities are backed by a team of highly skilled scientists and technicians with expertise in chemistry, biology, and pharmaceuticals. With decades of combined experience in isotopic technology, our team possesses the knowledge and proficiency to execute complex synthesis, labeling, and testing processes with precision and efficiency. We continuously invest in training and development to ensure that our personnel stay at the forefront of isotopic research and innovation.

Rigorous Quality Control Measures

In production of our isotopomeres, the most important is quality control. At ANSUN WEALTH through our QC team we maintain strict quality control at every level of production right from material procurement to its final delivery. Our Quality Review Protocols Include:

• Raw Material Selection: We supply high-quality starting materials and isotopic precursors in order for our products to be the best pureness and authenticity when it comes to raw materials.
• Synthesis and Labeling - We follow standardized protocols and best practices in production review to ensure a consistent and reliable solution.
• Analytical Testing: Perform detailed analytical testing on our products using cutting-edge instrumentation to validate purity, composition and isotopic enrichment.
• Qualifications : All of the isotopic products are subjected to a series of quality assurance tests according to our robust quality specifications before being released to the customer.

Innovation and Continuous Improvement

At BOC Sciences, we promise to keep improving our isotopic production. In doing this, we are currently heavily investing in R & D for new synthesis technologies, labeling methodologies, detection methods to improve and expand upon our existing offerings. Our dedication to innovation means we are in the forefront of industry changes and can adapt to the changing requirements of our clients in a variety of scientific fields.

Applications of BOC Sciences' Isotopic Services

The isotopic manufacturing capabilities of BOC Sciences have applications likely in many scientific fields, progress in several areas of research, industry, and academia is forged. We offer services for a wide range applications with our isotopic compounds it includes:

• Pharmaceutical R&D: Tracking drug metabolism, identifying toxicity, and developing new drugs.
• Environmental Studies: Analyzing environmental changes and plant growth.
• Biological Research: Studying protein dynamics, interactions, and modifications.
• Agriculture: Enhancing understanding of plant metabolism and growth processes.
• Food Science: Ensuring food safety and tracing origins.

BOC Sciences has remained faithful to produce a definitive, high-quality work product and therefore has essentially promote research and development in a variety of scientific fields.

Case Study

Unraveling Cancer Metabolism: Advancements in Stable Isotope-Resolved Metabolomics

Over the past few years, the development of advanced analytical technology such as nuclear magnetic resonance (NMR) and mass spectrometry (MS) has allowed extensive profiling of the human metabolome, fueling a resurging interest in metabolism in diseases like cancer [1]. By combining stable isotope tracers with metabolomics technologies, researchers can follow single atoms through metabolic networks, allowing new metabolic reprogramming in diseased state, identification of potential lead drug targets, and pharmacology and therapeutics. Scientists discuss the use of stable isotope-resolved metabolomics for deciphering metabolic reprogramming in colorectal cancer as a case where it excellently captures tumor metabolism, elucidates potential personalized therapeutic approaches, and contributes to progress in clinical diagnostics. The merging of isotope tracer-based imaging technologies with metabolomics data also facilitates real-time measurements of treatment response and tumor growth, demonstrating the transformative utility of this technology for advancing our understanding of systemic illnesses and paving the way for personalized therapeutic strategies.

FAQ

1. How are stable isotopes used in medicine?

Medical stable isotopes applications The MRI used to Image muscles, organs, joints, and many details in diagnosing diseases. They are tackled from the metabolic pathways they track in research and the way physiological processes are studied. Also specific isotopes destroy them offering the advantageous method other illnesses and most cancers radiation cure, minimizing damage to wholesome cells. This is why stable isotopes can greatly help in medical diagnosis, research, and treatment in general..

2. What is the isotopic tracer technique?

The stable isotope tracer method is the use of stable isotopes such as 13C, 15N, or deuterium to follow the movement of atoms through a system. Research focussed on exchanges between different atoms in molecules (e.g. substrates taken up by a biological sample for biosynthesis or metabolism) by substituting such atoms with their isotope, and monitoring their distributions over time, provides assistance in study of various biological or chemical events. It is a widely-used technique in biochemistry, medicine, and environmental science where it has also been employed in studying metabolism, nutrient cycling and reaction mechanisms.

3. Which isotope is useful tracer?

An isotope that is often used as a tracer in medical applications is carbon-13 (13C). In metabolic studies, it is frequently employed to follow the metabolic pathways and organ function. Nitrogen-15 (15N) and Oxygen-18 (18O) also are used as tracers in some medical research contexts. Each have different properties that lend them to specific applications and info one might be seeking.