Product List
BOC Sciences is committed to providing customers with isotope-labeled vitamins. We offer a complete range of labeled vitamins standards. All products come with comprehensive analytical data files and are of high chemical purity. With over 20 years of industry experience, BOC Sciences is at the forefront of innovation, ensuring the provision of safe, stable, and precise isotopic compounds for a wide range of scientific studies. In addition, we also provide custom isotope labeling service for any carbohydrates, you can directly provide the carbohydrates to be labeled or make a request such as the type of labeling isotope, the labeling site, and the isotope enrichment.
What are Vitamins?
Vitamins are a group of organic compounds that are essential for good health and play an important regulatory role in the metabolism of substances. If a vitamin is deficient for a long period of time, it can cause physiological disorders and lead to the development of certain diseases. They are typically obtained from dietary sources and are essential in small quantities for a range of bodily functions. The major categories of vitamins include fat-soluble vitamins (A, D, E, K) and water-soluble vitamins (C and B-complex).
What is the Vitamin Function?
- Hormone-like Functions: Some vitamins, such as vitamin D, function as hormones that regulate mineral metabolism and support bone health. Others, like certain forms of vitamin A, are involved in the regulation of cell and tissue growth and differentiation.
- Antioxidant Functions: Vitamins like E and C act as antioxidants, protecting cells from oxidative stress and damage.
- Enzyme Cofactors: Many B vitamins function as precursors for enzyme cofactors, which are essential for catalyzing metabolic reactions. For example, thiamine (B1) and riboflavin (B2) play critical roles in energy metabolism.
What are Isotope Labeled Vitamins?
Stable isotope labeled vitamins are safe and stable, non-radioactive and have a long half-life. Their mass spectra differ from their unlabeled counterparts, making them traceable for use as internal standards or tracking reagents for the analysis of vitamin uptake and metabolism. Over recent years, stable isotope labeled vitamins are the gold standard with regard of quantifying endogenous vitamin metabolites in complex biological matrices. A range of stable isotope labeled vitamins, including 2H, 13C, 15N, and 18O labeled vitamins, are currently used extensively for metabolic and pathophysiological explorations and for the assessment of disease biomarkers.
Our Isotope Labeling Services for Vitamins
BOC Sciences offers comprehensive isotope labeling services for vitamins, ensuring the highest standards of quality and precision. Our synthetic chemists have garnered an excellent reputation for producing high-quality, isotopically labeled vitamins. Each product is accompanied by a Certificate of Analysis confirming isotopic enrichment and chemical purity.
Labeling Types Options
We offer various labeling types for vitamins, including:
These isotopes are selected based on the specific requirements of the research or diagnostic application, ensuring optimal traceability and analytical performance.
Vitamins Types Options
Our extensive range of isotope-labeled vitamins includes:
- Vitamin A and its analogs
- Vitamin B Complex (B1, B2, B3, B6, B12, etc.)
- Vitamin C
- Vitamin D and its metabolites
- Vitamin E
- Vitamin K
For more types of vitamins (and their derivatives) and isotopic labeling, please contact us directly.
Applications of Isotope Labeled Vitamins
Isotope-labeled vitamins have become indispensable in various research and diagnostic applications:
- Metabolic Pathway Studies: By tracking labeled vitamins, researchers can study how these nutrients are metabolized in the body, offering insights into their utilization and the effects of various factors like diet and genetics.
- Pharmacokinetic Studies: These compounds are used to investigate the absorption, distribution, metabolism, and excretion of vitamins, aiding in the development of more effective supplementation strategies.
- Nutritional Research: Isotope-labeled vitamins are valuable in studying vitamin deficiencies, metabolic disorders, and the bioavailability of vitamins from different food sources or supplements.
- Disease Biomarker Assessment: They are employed in the identification and quantification of endogenous vitamin metabolites in complex biological matrices, facilitating the assessment of disease biomarkers.
Examples of Applications:
Application of Stable Isotope Labeled Vitamin B
The B vitamins are the basic substances that drive the conversion of all substances in the body into energy. They are involved in the metabolism of proteins, carbohydrates and fats, and are also essential for promoting the body's metabolism. As internal standards, stable isotope labeled thiamine, riboflavin, niacinamide, pyridoxine show the potential for the simultaneous determination of total vitamins B1, B2, B3 and B6 in infant foods and related nutritional products. A stable isotope labeling method based on essential nutrients in cell culture, including isotopically labeled niacinamide, is used to efficiently label the intracellular NAD(H) and NADP(H) pools. The method is combined with liquid chromatography high resolution mass spectrometry to track and quantify the metabolism of NAD(H) and NADP(H) in cells and tissues.
Application of Stable Isotope Labeled Vitamin C
Stable isotope labeled ascorbic acid has good stability and safety in vivo. Also, due to its enrichment behaviour in the body with minimal correlation to endogenous ascorbic acid, it has been widely used to identify and differentiate between freshly absorbed and endogenous vitamins in humans and thus to determine the pharmacokinetic properties of ascorbic acid. It can also be used for investigating the possible effects of other dietary components, such as ferrous ions and grape juice, on ascorbic acid absorption and metabolism in healthy adult subjects.
Application of Stable Isotope Labeled Vitamin E
Similarly, trideuterated α-tocopherol is used as an internal standard to assess overall vitamin E levels in humans by MS measurements. In addition, this stable isotope labeled vitamin E hydrolysis product can be used to study the kinetics of vitamin E metabolism in organisms exposed to oxidative stress and stressful environments (e.g. chronic inflammation, smoking, radiation, etc.).
Advantages of Isotope Labeled Vitamins
BOC Sciences' isotope-labeled vitamins offer several advantages:
- High Purity and Stability: Our vitamins are of high chemical purity and are stable, ensuring reliable and reproducible results.
- Non-Radioactive Safety: The stable isotopes used are non-radioactive, making them safe for use in both in vitro and in vivo studies.
- Comprehensive Analytical Data: Each product is accompanied by detailed analytical data, confirming its isotopic enrichment and purity.
- Gold Standard in Research: Our labeled vitamins are considered the gold standard for quantifying endogenous vitamin metabolites in complex biological matrices.
- Expertise and Support: With over 20 years of experience, BOC Sciences provides unparalleled expertise and customer support, helping researchers achieve their scientific goals efficiently.
BOC Sciences stands as a trusted partner in the field of isotope-labeled vitamins, offering top-quality products and services that cater to the advanced needs of biochemical and clinical research. Our commitment to excellence and innovation ensures that researchers have access to the best tools for exploring the complex world of vitamin metabolism and its impact on health and disease.
FAQ
1. What does vitamin D do?
Vitamin D plays an important role in the body. It helps in the absorption of calcium and phosphorus and ensures healthy bones and teeth. In addition, vitamin D has a positive effect on the immune system, nervous system, and muscle function.
2. What does vitamin C do?
Vitamin C, also known as ascorbic acid, is an important water-soluble vitamin that has multiple effects on human health. It is involved in collagen synthesis, helps wound healing, enhances immune system function, and has strong antioxidant capacity that can neutralize free radicals and reduce oxidative stress damage to cells.
3. What foods have vitamin A?
For example:
- Liver: Beef and chicken liver, in particular, are the best sources of vitamin A.
- Carrots: Rich in beta-carotene, which is converted into vitamin A in the body.
- Sweet potatoes: Also a good source of beta-carotene.
- Spinach: Rich in many nutrients, including vitamin A.
- Sweet potatoes: Contain high amounts of beta-carotene.
- Egg yolk: Contains natural vitamin A.
- Dairy products, such as milk and cheese, contain A certain amount of vitamin A.
4. What is vitamin B12?
Vitamin B12 (also known as cobalamin) is a water-soluble vitamin that is essential for the body's nervous system health and the production of red blood cells. It is involved in DNA synthesis and energy metabolism, and a lack of vitamin B12 can lead to anemia, nerve damage, and other health problems.
5. What foods have vitamin d?
Foods that contain vitamin D include cod liver oil, salmon, sardines, tuna, mushrooms, egg yolks, and fortified milk. Vitamin D helps with calcium absorption and is important for bone health.
6. What foods have vitamin d3?
There are many foods that contain vitamin D3, of which fish such as salmon, mackerel and tuna are very good sources. In addition, cod liver oil, especially cod liver oil, is also rich in vitamin D3. The yolk of an egg also contains vitamin D3.
7. What is vitamin K?
Vitamin K is a fat-soluble vitamin that is essential for blood clotting and bone health. It is mainly divided into vitamins K1 and K2, which are derived from green leafy vegetables and animal products respectively, and help maintain the balance of calcium in the body and prevent calcification of blood vessels and soft tissues.
