Stable isotope-labeled compounds are used as environmental pollutant standards for the detection of air, water, soil, sediment and food.
In addition to treating various diseases, isotopes are used for imaging, diagnosis, and newborn screening.
Small molecule compounds labeled with stable isotopes can be used as chemical reference for chemical identification, qualitative, quantitative, detection, etc. Various types of NMR solvents can be used to study the structure, reaction mechanism and reaction kinetics of compounds.
Stable isotope labeling allows researchers to study metabolic pathways in vivo in a safe manner.
BOC Sciences is committed to providing customers with isotope-labeled vitamins. We offer a complete range of labeled vitamins standards. All products come with comprehensive analytical data files and are of high chemical purity.
Stable isotope labeled vitamins are safe and stable, non-radioactive and have a long half-life. Their mass spectra differ from their unlabeled counterparts, making them traceable for use as internal standards or tracking reagents for the analysis of vitamin uptake and metabolism. Over recent years, stable isotope labeled vitamins are the gold standard with regard of quantifying endogenous vitamin metabolites in complex biological matrices. A range of stable isotope labeled vitamins, including 2H, 13C, 15N, and 18O labeled vitamins, are currently used extensively for metabolic and pathophysiological explorations and for the assessment of disease biomarkers.
Vitamins are a group of organic compounds that are essential for good health and play an important regulatory role in the metabolism of substances. If a vitamin is deficient for a long period of time, it can cause physiological disorders and lead to the development of certain diseases. They are generally obtained from food. There are dozens of them found at this stage, such as vitamin A, vitamin B complex, vitamin C, etc.
The B vitamins are the basic substances that drive the conversion of all substances in the body into energy. They are involved in the metabolism of proteins, carbohydrates and fats, and are also essential for promoting the body's metabolism. As internal standards, stable isotope labeled thiamine, riboflavin, niacinamide, pyridoxine show the potential for the simultaneous determination of total vitamins B1, B2, B3 and B6 in infant foods and related nutritional products. A stable isotope labeling method based on essential nutrients in cell culture, including isotopically labeled niacinamide, is used to efficiently label the intracellular NAD(H) and NADP(H) pools. The method is combined with liquid chromatography high resolution mass spectrometry to track and quantify the metabolism of NAD(H) and NADP(H) in cells and tissues.
Stable isotope labeled ascorbic acid has good stability and safety in vivo. Also, due to its enrichment behaviour in the body with minimal correlation to endogenous ascorbic acid, it has been widely used to identify and differentiate between freshly absorbed and endogenous vitamins in humans and thus to determine the pharmacokinetic properties of ascorbic acid. It can also be used for investigating the possible effects of other dietary components, such as ferrous ions and grape juice, on ascorbic acid absorption and metabolism in healthy adult subjects.
Similarly, trideuterated α-tocopherol is used as an internal standard to assess overall vitamin E levels in humans by MS measurements. In addition, this stable isotope labeled vitamin E hydrolysis product can be used to study the kinetics of vitamin E metabolism in organisms exposed to oxidative stress and stressful environments (e.g. chronic inflammation, smoking, radiation, etc.).