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Isotope Labeled Metabolites

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Metabolites, the intricate molecules that orchestrate cellular functions and signal the state of biological systems, serve as indispensable indicators in biological research and clinical diagnostics. These small molecules, whether intermediary or end products of metabolism, encapsulate the dynamic processes within cells, offering a snapshot of physiological health, disease states, and responses to therapeutic interventions. BOC Sciences is committed to providing customers with isotope-labeled metabolites. We offer the broadest range of metabolite and metabolomic standards. In addition, we also provide custom isotope labeling service for any metabolites, you can directly provide the metabolites to be labeled or make a request such as the type of labeling isotope, the labeling site, and the isotope enrichment.

What are Metabolites?

Metabolomics studies the intracellular and extracellular metabolites in biological systems, which provides abundant information for metabolic changes in organisms, and has been widely used in drug development, clinical diagnosis, and pathological research. Most research objects of metabolomics relate to small-molecule metabolites with a molecular weight of less than 1000. Metabolites refer to intermediate and final metabolites produced in activities such as metabolism. As intermediates and final products of biological processes, metabolites are important indicators of physiological processes, pathological processes, and pharmaceutical responses to therapeutic interventions. Studying the changes of metabolites provide insight into metabolic pathways and disease mechanisms and contributes to the diagnosis, treatment, and prognosis of diseases. Metabolites encompass a diverse array of molecules involved in metabolic pathways, including amino acids, lipids, sugars, nucleotides, and numerous other organic compounds. They play pivotal roles as building blocks for cellular structures, energy sources, and signaling molecules essential for maintaining cellular homeostasis and overall organismal health.

Function of Metabolites

  • Energy Production: Metabolites such as ATP (adenosine triphosphate) are vital energy carriers in cells, fueling biochemical reactions necessary for life.
  • Building Blocks: Amino acids derived from metabolites serve as precursors for protein synthesis and nucleotide synthesis essential for DNA and RNA formation.
  • Signaling and Regulation: Metabolites act as signaling molecules, regulating enzymatic activities, gene expression, and cellular responses to environmental stimuli.

What are Isotope Labeled Metabolites?

Isotope labeling technology has been characterized by high rapidity, sensitivity, simplicity, accuracy, and localization capability and has become an indispensable technique for studying biological metabolism. Isotope-labeled metabolites enable the accurate identification of complex metabolites and trace biosynthetic pathways of specific compounds. Moreover, isotopic types and ratios of metabolites provide valuable information for further research. Isotope labeled metabolites are synthetic variants where stable isotopes, such as Carbon-13, Nitrogen-15, Deuterium or Oxygen-18, are strategically incorporated into specific positions within the molecular structure. This labeling technique enables researchers to track the metabolic fate of these molecules with precision using advanced analytical methods such as nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry (MS).

Advantages of Isotope Labeled Metabolites

The utilization of isotope labeled metabolites offers several distinct advantages in metabolic research:

  • Enhanced Sensitivity: Isotope labeling significantly enhances the detection sensitivity of metabolites, allowing researchers to identify and quantify low-abundance compounds in complex biological matrices.
  • Pathway Tracing: By tracing the fate of labeled metabolites, researchers can elucidate metabolic pathways, discerning biochemical transformations and fluxes within cellular systems.
  • Quantitative Analysis: Isotope labeling facilitates precise quantitative analysis of metabolic dynamics, providing quantitative insights into metabolic rates and turnover.
  • Selective Detection: Isotope labeling enables selective detection of specific metabolites, isolating them from the background noise of biological samples for accurate analysis.

Our Isotope Labeling Services for Metabolites

At BOC Sciences, we specialize in providing comprehensive isotope labeling services tailored for metabolomics research and applications. Our commitment to excellence in scientific innovation and precision allows us to offer a broad spectrum of labeled metabolites essential for advancing metabolic pathway analysis and biomedical research.

Labeling Options

Dual & Multi Isotope Labeling

Combining two different isotopes to enhance analytical capabilities, providing richer data on metabolic pathways and interactions.

Deuterium Labeling (2H)

Deuterium labeling offers unique advantages in tracking metabolic pathways and studying biochemical reactions, particularly in lipidomics and drug metabolism studies.

Carbon-13 Labeling (13C)

Incorporation of 13C isotopes into metabolite structures enhances resolution and sensitivity in NMR spectroscopy, facilitating detailed metabolic profiling.

Nitrogen-15 Labeling (15N)

Utilization of 15N isotopes enables robust quantification and pathway tracing of nitrogen-containing metabolites, crucial for comprehensive metabolic flux analysis.

Oxygen-18 Labeling (18O)

18O labeling provides a unique tool for studying oxygen exchange processes and metabolic pathways involving oxygenated compounds.

For more types of peptides (and their derivatives) and isotopic labeling, please contact us directly.

Applications of Isotope Labeled Metabolites

With the help of isotope labeling technology, you can track the metabolic laws of labeled compounds in the body, clarify the activity trajectories of isotope-labeled metabolites in relevant metabolic pathways, and discover the corresponding relationship between metabolites and physiological pathological changes so to explore the mechanism of disease. Isotope-labeled metabolites have been widely used in the study of metabolism, revealing the complexity and plasticity of metabolism and enlightening effective methods for preventing and treating disease.

Metabolic Pathway Analysis

Detailed elucidation of metabolic pathways, including amino acid metabolism, lipid metabolism, and nucleotide synthesis.

Biomarker Discovery

Identification of biomarkers indicative of disease states or responses to therapeutic interventions, enhancing diagnostic and prognostic capabilities.

Drug Development

Evaluation of drug metabolism and pharmacokinetics, optimizing drug efficacy and safety profiles through metabolic stability studies.

By harnessing the power of isotope labeled metabolites, you can unlock new dimensions of metabolic research, driving innovations across various fields and improving health outcomes. BOC Sciences is committed to supporting these endeavors with our state-of-the-art isotope labeling services and expertise, empowering scientists to make groundbreaking discoveries and advance the frontiers of biological research.

Why Choose BOC Sciences' Isotope Labeled Metabolites?

Choosing BOC Sciences ensures access to:

  • Expertise and Experience: With over 20 years of experience in the industry, we bring unparalleled expertise in isotope labeling and metabolomics.
  • Customized Solutions: Tailored labeling strategies to meet specific research objectives, ensuring high-quality data and reliable results.
  • Comprehensive Support: From synthesis and labeling to analytical characterization, our integrated services streamline research workflows, accelerating scientific discoveries.

Isotope labeled metabolites represent a cornerstone in modern metabolomics, offering precise insights into biological systems' metabolic intricacies. At BOC Sciences, we are dedicated to empowering researchers with cutting-edge tools and solutions to unravel the complexities of metabolism, driving advancements in biomedical research and personalized medicine.


1. What are secondary metabolites?

Secondary metabolites are small molecules that are synthesized through secondary metabolism after the growth of an organism to a certain stage and have a very complex molecular structure, have no obvious physiological function for the organism, or are not essential for the growth and reproduction of the organism, e.g. antibiotics and hormones.

2. What is drug metabolites?

Drug metabolism refers to the process in which a drug's chemical structure is altered through the action of various drug-metabolizing enzymes within the body, also known as biotransformation. There are two possible outcomes of drug biotransformation in the body: first, the drug may be inactivated, resulting in a metabolite with no pharmacological activity; second, the drug may be activated, converting from an inactive state against certain organ targets to a metabolite with pharmacological activity, or even producing a toxic metabolite. Additionally, some drugs' metabolites may retain their original pharmacological effects.

3. How to label metabolites?

Labeling metabolites typically involves using techniques such as mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy for identification and structural elucidation. Chromatography methods like HPLC and GC are employed for separation. Additionally, isotopic labeling with stable or radioactive isotopes can be used to trace metabolic pathways and identify metabolites accurately.

4. Why is isotope labeling important?

Isotope labeling is important because it allows precise tracking and identification of molecules in biological systems. It helps in mapping metabolic pathways, quantifying metabolites, and understanding drug metabolism with high sensitivity and specificity. This technique is essential for studying biochemical reactions and interactions in cells.

5. What are the most common metabolites?

Common metabolites include glucose and its derivatives such as lactic acid, amino acids and their derivatives such as glutamate and alanine, fatty acids such as short-chain fatty acids, and nucleotides and nucleosides. These metabolites play a vital role in biological processes such as cell signaling, energy conversion and substance synthesis.

6. What are the types of metabolites?

Metabolites are broadly categorized into primary and secondary types. Primary metabolites are essential for basic biological functions like growth and energy production. Secondary metabolites, while not essential for growth, play roles in defense, signaling, and ecological interactions, such as producing antibiotics or attracting pollinators.

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