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Isotope labeled peptides represent a cornerstone in modern biomedical research, offering unparalleled insights into the complex dynamics of biological systems. At BOC Sciences, we recognize the critical role these peptides play in advancing proteomics, pharmacokinetics, structural biology. Here, we offer a complete range of labeled peptides with stable quality, and our custom peptides labeled with stable isotopes include 2H (deuterium), 15N, 13C, 18O. In addition, we also provide custom isotope labeling service for any peptides, you can directly provide the peptides to be labeled or make a request such as the type of labeling isotope, the labeling site, and the isotope enrichment.

What is a Peptide?

Peptides are short chains of amino acids linked by peptide bonds, typically comprising fewer than 50 amino acid residues. These biomolecules serve diverse biological functions, from signaling and enzyme regulation to structural support within cells. In research, peptides are invaluable tools for studying protein-protein interactions, receptor-ligand binding, and as therapeutic agents in drug development. Many peptides are synthesized in the nervous system, lymphoid tissue, and endocrine system. Peptides have strong biological activities and can regulate the functional activities of cells in living organisms, and maintain various roles in medicine, cosmetics, food.

What are Peptides Used for?

• Biological Signaling and Regulation: Peptides act as signaling molecules in hormone regulation, neurotransmission, immune response modulation, and cell growth. Peptides are essential in biochemical assays, proteomics, and structural biology techniques like X-ray crystallography and mass spectrometry.
• Drug Development: With the continuous development of modern biotechnology, the study of peptide drugs, which can be used for anti-tumor, anti-virus, anti-bacterial, diagnosis, etc., has become increasingly essential for disease prevention and treatment.
• Diagnostic Biomarkers: Peptides serve as biomarkers for disease detection and monitoring in clinical diagnostics.
• Cosmetics: Peptides reserved characteristics such as high biological activity, easy absorption, safe and non-toxic, and are widely used in cosmetic products. Bioactive peptides were further advanced with characteristics such as anti-aging, repairing, antioxidant, and other biological functions.
• Food and Agriculture: Peptides are used as nutritional supplements and functional factors in food products to improve or alter nutritional metabolism, fat metabolism, glucose metabolism, and regulation of nervous systems.

What are Isotope Labeled Peptides?

Isotope labeled peptides are synthetic peptides where one or more atoms within the peptide structure are replaced with stable isotopes of elements like hydrogen (2H or deuterium), carbon (13C), nitrogen (15N), or oxygen (18O). These stable isotopes replace their natural counterparts, which are typically more abundant and have different atomic masses. The substitution of isotopes imparts unique properties to the peptides that are advantageous in various scientific applications, particularly in analytical techniques such as mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy.

Why Labeled Peptides with Isotopes?

The primary purposes of incorporating stable isotopes into peptides include enhancing the sensitivity and specificity of detection methods, enabling accurate quantification of peptides and proteins in complex biological samples, and facilitating studies on protein dynamics, metabolism, and structure. Isotope labeled peptides serve as internal standards or probes in quantitative proteomics, metabolic labeling experiments, targeted proteomics assays, pharmacokinetic studies, and structural biology investigations. These peptides play a crucial role in advancing biomedical research by providing researchers with tools to explore protein interactions, characterize biomolecular structures, develop new therapies, and understand disease mechanisms at a molecular level.

Our Isotope Labeling Services for Peptides

At BOC Sciences, we offer specialized isotope labeling services for peptides, leveraging our expertise in synthetic chemistry and analytical techniques. Isotope labeling enhances the utility of peptides in various applications, providing researchers with powerful tools for quantitative analysis, structural elucidation, and biomedical research.

Comprehensive Labeling Options

• Dual / multi Isotope Labeling
• Deuterium Labeling (2H): Enhances peptide stability and aids in NMR studies.
• Carbon-13 Labeling (13C): Facilitates high-resolution mass spectrometry and metabolic flux analysis.
• Nitrogen-15 Labeling (15N): Enables precise quantification and protein dynamics studies.
• Oxygen-18 Labeling (18O)

For more types of peptides (and their derivatives) and isotopic labeling, please contact us directly.

What are Isotope Labeled Peptides Used For?

Stable isotope labeled peptides represent a cornerstone in modern biomedical research, offering versatile applications across various scientific disciplines. These peptides, enriched with stable isotopes such as deuterium (2H), carbon-13 (13C), and nitrogen-15 (15N), provide unique capabilities that significantly enhance the scope and precision of experimental methodologies. Below are key applications where stable isotope labeled peptides play a pivotal role:

Quantitative Proteomics

By serving as internal standards, labeled peptides enable accurate measurement of protein abundances in complex biological samples. This is pivotal for biomarker discovery and validation studies.

Metabolic Labeling

Tracking labeled peptides in metabolic studies allows researchers to study protein turnover, post-translational modifications (PTMs), and protein-protein interactions.

Structural Biology

Isotope labeling combined with techniques like NMR and X-ray crystallography provides detailed insights into protein structure, aiding in drug design and understanding disease mechanisms.

Pharmacokinetics and Drug Metabolism

Labeled peptides are essential in studying drug absorption, distribution, metabolism, and excretion (ADME), informing drug development processes.

Targeted Proteomics

Used in techniques such as selected reaction monitoring (SRM) for precise quantification of specific peptides or proteins, crucial in clinical diagnostics and personalized medicine.

Why Choose BOC Sciences' Isotope Labeled Peptides?

• Expertise and Innovation: With over 20 years of experience in the industry, BOC Sciences combines deep scientific expertise with state-of-the-art technologies to deliver high-quality isotope labeled peptides that meet the most demanding research requirements.
• Customization: We offer flexible solutions, tailoring peptide labeling to unique project needs, ensuring optimal performance and reliability in experimental outcomes.
• Quality Assurance: Rigorous quality control measures, including mass spectrometry and high-performance liquid chromatography (HPLC) analysis, guarantee the purity, efficiency, and accuracy of our labeled peptides.
• Timely Delivery: Committed to accelerating research timelines, BOC Sciences prioritizes quick turnaround times without compromising on the quality of our services.

Isotope labeled peptides from BOC Sciences represent a pivotal tool in advancing scientific discovery across diverse fields of biomedical research. By harnessing the power of stable isotopes, researchers gain unprecedented insights into biological processes, paving the way for innovative therapies and diagnostic tools. Partner with BOC Sciences to unlock the full potential of isotope labeled peptides in your research endeavors.

FAQ

1. What is glucagon-like peptide-1?

Glucagon-like peptide-1 (GLP-1) is a brain-gut peptide secreted by endocrine cells in the ileum, and is currently used as a target for type 2 diabetes drugs. Since GLP-1 inhibits gastric emptying and reduces intestinal motility, it helps to control food intake and reduce body weight.

2. What are collagen peptides?

Collagen peptide is a small molecule peptide, which is a product obtained from collagen through a specific enzymatic process. Compared with collagen, collagen peptide has a smaller molecular weight and is more easily absorbed by the body. Collagen peptide has the effect of improving skin elasticity and delaying aging.

3. What is a peptide bond?

A peptide bond is an amide bond formed by the dehydration condensation of the α-carboxy group of one molecule of amino acids and the α-amino group of one molecule of amino acids, i.e. -CO-NH-. Amino acids are linked by peptide bonds to form polypeptide chains. It is the main covalent bond in protein molecules and is relatively stable in nature.

4. What is brain natriuretic peptide?

Brain natriuretic peptide is an active substance secreted by cardiomyocytes, which has favorable effects on the cardiovascular system, including sodium diuresis and diuresis to expel excess water from the body. In addition, it has a certain vasodilating effect, can reduce the anterior and posterior load of the heart, and has a certain protective effect on patients with cardiac insufficiency. Since brain natriuretic peptide is a substance first found in pig brain, it is less related to the brain and is an active substance secreted by cardiomyocytes, which mainly acts on the cardiovascular system.

5. What are peptides in skincare?

Peptides in cosmetics are short chains of amino acids. These peptides can penetrate the upper layers of the skin and act as messengers that trigger specific functions, such as enhancing skin firmness, thickness, and elasticity, often in conjunction with collagen. Peptides with these properties help combat aging. Based on their mechanisms of action, peptides used in cosmetics are categorized into three types: (1) signaling peptides, (2) carrier peptides, and (3) neurotransmitter-inhibiting peptides.

6. What is peptide therapy?

Peptide therapy involves the use of peptides—short chains of amino acids—as therapeutic agents in medicine. These peptides can mimic or block the actions of naturally occurring peptides in the body. Peptide therapy can target various physiological processes such as hormone regulation, immune response modulation, inflammation control, and tissue repair.

7. What is cyclic citrullinated peptide?

Cyclic citrullinated peptide (CCP) is a specific type of peptide that plays a significant role in the diagnosis of rheumatoid arthritis (RA). It is derived from a protein called filaggrin, which undergoes citrullination—a post-translational modification where arginine residues in the protein are converted to citrulline by the enzyme peptidyl arginine deiminase (PAD).