Stable isotope labeling allows researchers to study metabolic pathways in vivo in a safe manner.
Stable isotope-labeled compounds are used as environmental pollutant standards for the detection of air, water, soil, sediment and food.
In addition to treating various diseases, isotopes are used for imaging, diagnosis, and newborn screening.
Small molecule compounds labeled with stable isotopes can be used as chemical reference for chemical identification, qualitative, quantitative, detection, etc. Various types of NMR solvents can be used to study the structure, reaction mechanism and reaction kinetics of compounds.
Stable isotope labeling allows researchers to study metabolic pathways in vivo in a safe manner.
Stable isotope-labeled compounds are used as environmental pollutant standards for the detection of air, water, soil, sediment and food.
General Information |
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Catalog: BLP-011397 |
CAS: 2342575-79-3 |
Molecular Formula: C41H75D5NO8P |
Molecular Weight: 751.09 |
Chemical Structure |
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Synonyms | 1-heptadecanoyl-2-palmitoleoyl-sn-glycero(d5)-3-phosphocholine; 17:0-16:1 PC-d5; PC 17:0-16:1-d5; PC(17:0/16:1(9Z))-d5; 1-heptadecanoyl-2-(9Z-hexadecenoyl)-glycero-3-phosphocholine-d5 |
IUPAC Name | [(2R)-1,1,2,3,3-pentadeuterio-3-heptadecanoyloxy-2-[(Z)-hexadec-9-enoyl]oxypropyl] 2-(trimethylazaniumyl)ethyl phosphate |
Canonical SMILES | CCCCCCCCCCCCCCCCC(=O)OCC(COP(=O)([O-])OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCC |
InChI | InChI=1S/C41H80NO8P/c1-6-8-10-12-14-16-18-20-22-23-25-27-29-31-33-40(43)47-37-39(38-49-51(45,46)48-36-35-42(3,4)5)50-41(44)34-32-30-28-26-24-21-19-17-15-13-11-9-7-2/h17,19,39H,6-16,18,20-38H2,1-5H3/b19-17-/t39-/m1/s1/i37D2,38D2,39D |
InChI Key | DISVYZNGGMDUPX-FEZSZEOVSA-N |
Purity | >99% |
Solubility | Soluble in DCM, Methanol |
Appearance | Liquid |
Shelf Life | 1 Year |
Storage | Store at -20°C |
17:0-16:1 PC-[d5], a deuterated phosphatidylcholine lipid, stands at the forefront of scientific and industrial research realms. Here are key applications of 17:0-16:1 PC-[d5] presented with high perplexity and burstiness:
Lipidomics Research: Embarking on the complex voyage of lipidomics, 17:0-16:1 PC-[d5] emerges as a pivotal internal standard, enabling the meticulous quantification of lipids in biological samples. Its unique mass, a consequence of deuteration, facilitates precise measurement in mass spectrometry-based analyses. This precision empowers researchers to delve deep into lipid metabolism profiles, illuminating the intricate role of lipids in both realms of health and disease scenarios.
Membrane Dynamics Studies: In the realm of cellular membrane dynamics, 17:0-16:1 PC-[d5] emerges as a steadfast ally, offering profound insights into the distribution and dynamics of lipids within cellular membranes. By integrating this specially labeled lipid into model membranes, scientists embark on a captivating journey to unravel the intricacies of membrane organization, fluidity dynamics, and interactions with proteins—laying the groundwork to comprehend the intricate mechanisms underlying vital membrane-related processes such as cell signaling cascades.
Pharmacokinetics: Positioned on the cutting edge of drug development, 17:0-16:1 PC-[d5] emerges as an indispensable tool for dissecting the pharmacokinetics and biodistribution patterns of lipid-based drug delivery systems. By employing this deuterated lipid as a guiding beacon, researchers deftly navigate the complexities of how drugs loaded within lipid carriers traverse distribution pathways and metabolic processes within the human body. This invaluable insight propels the optimization of drug formulation strategies and delivery mechanisms, heralding a new era of precision medicine.
Environmental Toxicology: The domain of environmental toxicology witnesses the enlightening influence of 17:0-16:1 PC-[d5], facilitating the assessment of bioaccumulation and unveiling the disruptive effects of contaminants on lipid profiles within organisms. By tracing the fingerprints left by environmental toxins on lipid metabolism, researchers deepen their comprehension of the intricate interplay between toxins and cellular functions, paving the way toward crafting robust strategies to mitigate the ecological impacts of pollutants on our delicate ecosystem.
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