Stable isotope labeling allows researchers to study metabolic pathways in vivo in a safe manner.
Stable isotope-labeled compounds are used as environmental pollutant standards for the detection of air, water, soil, sediment and food.
In addition to treating various diseases, isotopes are used for imaging, diagnosis, and newborn screening.
Small molecule compounds labeled with stable isotopes can be used as chemical reference for chemical identification, qualitative, quantitative, detection, etc. Various types of NMR solvents can be used to study the structure, reaction mechanism and reaction kinetics of compounds.
Stable isotope labeling allows researchers to study metabolic pathways in vivo in a safe manner.
Stable isotope-labeled compounds are used as environmental pollutant standards for the detection of air, water, soil, sediment and food.
General Information |
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Catalog: BLP-013237 |
Molecular Formula: C4[13C]H12O5 |
Molecular Weight: 153.14 |
Chemical Structure |
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Description | Labelled D-Ribitol is used in the preparation of L-ribose and and arabinose, as well as a diagnostic tool for identifying human bladder cancer (HBC) through noninvasive urinary metabonomics. |
Synonyms | [3-13C]ribitol; [3-13C]adonitol; ribitol-3-13C |
IUPAC Name | (2R,3s,4S)-pentane-1,2,3,4,5-pentaol-3-13C |
Related CAS | 488-81-3 (unlabelled) |
Purity | 98% (CP); 98% atom 13C |
Solubility | Soluble in DMSO, Methanol |
Appearance | White to Off-White Solid |
Storage | Store at -20°C |
D-Ribitol-[3-13C], a monosaccharide with a distinctive isotopic label, is a versatile asset in various research domains. Here are the key applications of D-Ribitol-[3-13C]:
Metabolic Tracing: In the realm of metabolic tracing, D-Ribitol-[3-13C] emerges as a pivotal tool for tracking the trajectory of carbon atoms along intricate metabolic pathways. By infusing the labeled compound into biological systems, researchers can meticulously monitor its integration into diverse metabolic intermediates. This elucidates the fluidity of metabolites and unveils the dynamic interplay within biochemical processes.
NMR Spectroscopy: With its [3-13C] label, D-Ribitol-[3-13C] stands out as a prime candidate for Nuclear Magnetic Resonance (NMR) spectroscopy explorations. Scientists leverage this compound to glean intricate structural and dynamic insights into molecules dissolved in solution. This aids in unraveling conformational nuances, molecular interactions, and the dynamic behavior of ribitol-containing compounds.
Glycoprotein Analysis: Delving into the structural intricacies of glycoproteins, D-Ribitol-[3-13C] serves as a critical player in dissecting the composition of glycan chains. By targeting ribitol moieties within glycoproteins, scientists can scrutinize the arrangement and architecture of glycan structures with heightened precision. This knowledge is pivotal for deciphering the nuances of protein folding, trafficking dynamics, and functional attributes.
Biomedical Research: At the forefront of biomedical inquiry, D-Ribitol-[3-13C] assumes a pivotal role in probing metabolic shifts underlying ailments like cancer and metabolic disorders. By tracing the path of labeled ribitol in cells derived from patients or animal models, researchers unravel the metabolic alterations driving disease progression. This pursuit of understanding metabolic dynamics paves the way for identifying potential biomarkers crucial for the development of diagnostic modalities and therapeutic interventions.
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