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5-hydroxymethyl-2'-deoxycytidine-[hydroxymethyl-d2,6-d]

General Information
Catalog: BLP-007137
Molecular Formula: C10H12D3N3O5
Molecular Weight: 260.26
Chemical Structure
5-hydroxymethyl-2'-deoxycytidine-[hydroxymethyl-d2,6-d]
Synonyms 5-hydroxymethyl-2'-deoxycytidine-d3
IUPAC Name 4-amino-5-(hydroxymethyl)-1-[(2R,4S,5R)-2,3,3-trideuterio-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
Related CAS 7226-77-9 (unlabelled)
Canonical SMILES C1C(C(OC1N2C=C(C(=NC2=O)N)CO)CO)O
InChI InChI=1S/C10H15N3O5/c11-9-5(3-14)2-13(10(17)12-9)8-1-6(16)7(4-15)18-8/h2,6-8,14-16H,1,3-4H2,(H2,11,12,17)/t6-,7+,8+/m0/s1/i1D2,8D
InChI Key HMUOMFLFUUHUPE-JFNIZHGQSA-N
Melting Point 198-202°C
Purity 98% by CP; 98% atom D
Solubility Soluble in DMSO, Methanol, Water
Appearance White Solid
Storage Store at -20°C

5-hydroxymethyl-2'-deoxycytidine-[hydroxymethyl-d2,6-d], a labeled nucleoside with diverse scientific applications, particularly in epigenetics and molecular biology, is known for its versatility. Here are key applications of this compound presented with high perplexity and burstiness:

Cellular Metabolism Studies: Through its integration into DNA during replication, this compound allows researchers to delve into DNA modification and the role of hydroxymethylcytosine in cellular dynamics. By meticulously tracking its integration, scientists can uncover the intricate dance of DNA methylation and its cascading effects on gene expression. These studies are pivotal for unraveling the mysteries of cellular metabolism and the orchestration of genetic material.

Epigenetic Research: Widely harnessed in epigenetic inquiries, 5-hydroxymethyl-2'-deoxycytidine-[hydroxymethyl-d2,6-d] serves as a beacon in exploring the distribution and functions of 5-hydroxymethylcytosine across various cell lineages. It acts as a guiding light in unraveling the molecular underpinnings of epigenetic governance and its far-reaching implications in development and disease pathogenesis. This research lays the foundation for pinpointing novel therapeutic targets in maladies like cancer, reshaping the landscape of treatment strategies.

Cancer Research: At the forefront of cancer investigations, researchers leverage this compound to navigate the altered methylation landscapes within cancerous cells, shedding light on the intricacies of tumor biology. By charting the modifications of hydroxymethylcytosine, scientists can pinpoint potential biomarkers crucial for cancer detection and prognostication. This innovative approach fuels the development of targeted therapies aimed at rebalancing the epigenetic aberrations at play in cancer progression.

Advanced Molecular Diagnostics: Within molecular diagnostic paradigms, 5-hydroxymethyl-2'-deoxycytidine-[hydroxymethyl-d2,6-d] emerges as a gold standard, a beacon of accuracy in validating detection methods for hydroxymethylated cytosines. This validation process is pivotal for ensuring the fidelity of epigenetic profiling in clinical samples, paving the way for robust diagnostic platforms. These meticulous diagnostics empower clinicians with deep insights into the epigenetic alterations accompanying various diseases.

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