Stable isotope labeling allows researchers to study metabolic pathways in vivo in a safe manner.
Stable isotope-labeled compounds are used as environmental pollutant standards for the detection of air, water, soil, sediment and food.
In addition to treating various diseases, isotopes are used for imaging, diagnosis, and newborn screening.
Small molecule compounds labeled with stable isotopes can be used as chemical reference for chemical identification, qualitative, quantitative, detection, etc. Various types of NMR solvents can be used to study the structure, reaction mechanism and reaction kinetics of compounds.
Stable isotope labeling allows researchers to study metabolic pathways in vivo in a safe manner.
Stable isotope-labeled compounds are used as environmental pollutant standards for the detection of air, water, soil, sediment and food.
General Information |
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Catalog: BLP-007137 |
Molecular Formula: C10H12D3N3O5 |
Molecular Weight: 260.26 |
Chemical Structure |
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Synonyms | 5-hydroxymethyl-2'-deoxycytidine-d3 |
IUPAC Name | 4-amino-5-(hydroxymethyl)-1-[(2R,4S,5R)-2,3,3-trideuterio-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one |
Related CAS | 7226-77-9 (unlabelled) |
Canonical SMILES | C1C(C(OC1N2C=C(C(=NC2=O)N)CO)CO)O |
InChI | InChI=1S/C10H15N3O5/c11-9-5(3-14)2-13(10(17)12-9)8-1-6(16)7(4-15)18-8/h2,6-8,14-16H,1,3-4H2,(H2,11,12,17)/t6-,7+,8+/m0/s1/i1D2,8D |
InChI Key | HMUOMFLFUUHUPE-JFNIZHGQSA-N |
Melting Point | 198-202°C |
Purity | 98% by CP; 98% atom D |
Solubility | Soluble in DMSO, Methanol, Water |
Appearance | White Solid |
Storage | Store at -20°C |
5-hydroxymethyl-2'-deoxycytidine-[hydroxymethyl-d2,6-d], a labeled nucleoside with diverse scientific applications, particularly in epigenetics and molecular biology, is known for its versatility. Here are key applications of this compound presented with high perplexity and burstiness:
Cellular Metabolism Studies: Through its integration into DNA during replication, this compound allows researchers to delve into DNA modification and the role of hydroxymethylcytosine in cellular dynamics. By meticulously tracking its integration, scientists can uncover the intricate dance of DNA methylation and its cascading effects on gene expression. These studies are pivotal for unraveling the mysteries of cellular metabolism and the orchestration of genetic material.
Epigenetic Research: Widely harnessed in epigenetic inquiries, 5-hydroxymethyl-2'-deoxycytidine-[hydroxymethyl-d2,6-d] serves as a beacon in exploring the distribution and functions of 5-hydroxymethylcytosine across various cell lineages. It acts as a guiding light in unraveling the molecular underpinnings of epigenetic governance and its far-reaching implications in development and disease pathogenesis. This research lays the foundation for pinpointing novel therapeutic targets in maladies like cancer, reshaping the landscape of treatment strategies.
Cancer Research: At the forefront of cancer investigations, researchers leverage this compound to navigate the altered methylation landscapes within cancerous cells, shedding light on the intricacies of tumor biology. By charting the modifications of hydroxymethylcytosine, scientists can pinpoint potential biomarkers crucial for cancer detection and prognostication. This innovative approach fuels the development of targeted therapies aimed at rebalancing the epigenetic aberrations at play in cancer progression.
Advanced Molecular Diagnostics: Within molecular diagnostic paradigms, 5-hydroxymethyl-2'-deoxycytidine-[hydroxymethyl-d2,6-d] emerges as a gold standard, a beacon of accuracy in validating detection methods for hydroxymethylated cytosines. This validation process is pivotal for ensuring the fidelity of epigenetic profiling in clinical samples, paving the way for robust diagnostic platforms. These meticulous diagnostics empower clinicians with deep insights into the epigenetic alterations accompanying various diseases.
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