Stable isotope labeling allows researchers to study metabolic pathways in vivo in a safe manner.
Stable isotope-labeled compounds are used as environmental pollutant standards for the detection of air, water, soil, sediment and food.
In addition to treating various diseases, isotopes are used for imaging, diagnosis, and newborn screening.
Small molecule compounds labeled with stable isotopes can be used as chemical reference for chemical identification, qualitative, quantitative, detection, etc. Various types of NMR solvents can be used to study the structure, reaction mechanism and reaction kinetics of compounds.
Stable isotope labeling allows researchers to study metabolic pathways in vivo in a safe manner.
Stable isotope-labeled compounds are used as environmental pollutant standards for the detection of air, water, soil, sediment and food.
General Information |
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Catalog: BLP-014103 |
Molecular Formula: C8H8D8N2O3 |
Molecular Weight: 196.27 |
Chemical Structure |
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Synonyms | N-Epsilon-acetyl-L-lysine-d8; H-Lys(Ac)-OH-d8; L-ε-N-Acetyllysine-d8; N6-Acetyllysine-d8; NSC 102777-d8; Nε-Acetyl-L-lysine-d8; Nε-Acetyllysine-d8; ε-Acetyl-L-lysine-d8; ε-N-Acetyl-L-lysine-d8; ε-N-Acetyllysine-d8; ω-N-Acetyl-L-lysine-d8; (S)-6-Acetamido-2-aminohexanoic acid-d8; N6-Acetyl-L-lysine-d8 |
IUPAC Name | (2S)-6-acetamido-2-amino-3,3,4,4,5,5,6,6-octadeuteriohexanoic acid |
Related CAS | 692-04-6 (unlabelled) |
Canonical SMILES | CC(=O)NCCCCC(C(=O)O)N |
InChI | InChI=1S/C8H16N2O3/c1-6(11)10-5-3-2-4-7(9)8(12)13/h7H,2-5,9H2,1H3,(H,10,11)(H,12,13)/t7-/m0/s1/i2D2,3D2,4D2,5D2 |
InChI Key | DTERQYGMUDWYAZ-IYVSXXDFSA-N |
Melting Point | 237-239°C |
Purity | 95% by HPLC; 98% atom D |
Solubility | Soluble in Methanol (Slightly), Water (Slightly) |
Appearance | White to Off-white Solid |
Storage | Store at -20°C under inert atmosphere |
6-N-Acetyl-L-lysine-[3,3,4,4,5,5,6,6-d8] is a deuterated amino acid derivative with various applications in research and industry. Here are some key applications of 6-N-Acetyl-L-lysine-[3,3,4,4,5,5,6,6-d8]:
Protein Structure Analysis: 6-N-Acetyl-L-lysine-[3,3,4,4,5,5,6,6-d8] is utilized in NMR spectroscopy for detailed protein structure analysis. The deuterium labeling allows researchers to differentiate between hydrogen atoms and gain clearer insights into the protein’s conformation. This is essential for understanding protein folding, dynamics, and interactions.
Metabolic Flux Analysis: This deuterated compound can be used in metabolic flux analysis (MFA) to study amino acid incorporation and turnover in metabolic pathways. By tracing the labeled lysine through cellular processes, scientists can quantify metabolic rates and pathway activities. This is valuable for optimizing metabolic engineering and understanding cellular metabolism.
Epigenetic Modification Studies: 6-N-Acetyl-L-lysine-[3,3,4,4,5,5,6,6-d8] serves as a labeled substrate to investigate histone acetylation patterns in epigenetics research. The deuterium label allows for precise detection of modifications and their effects on gene expression. This helps unravel the complexities of epigenetic regulation and its implications in health and disease.
Pharmaceutical Development: In the pharmaceutical industry, this compound can be used to study drug interactions and stability. The deuterium atoms improve the detection of metabolites and degradation products in drug development studies. This aids in optimizing drug formulations and ensuring the efficacy and safety of new therapeutics.
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