Name: 9-Amino-1,2,3,4-tetrahydroacridin-1-ol-[d3] Maleate
Brand: BOC Sciences
Rating: 5 (1 reviews)

General Information

Catalog: BLP-013008

CAS: 1219806-48-0

Molecular Formula: C17H15D3N2O5

Molecular Weight: 333.36

Chemical Structure

Description	9-Amino-1,2,3,4-tetrahydroacridin-1-ol-[d3] Maleate is the labelled analogue of 9-Amino-1,2,3,4-tetrahydroacridin-1-ol Maleate, which is an impurity of Tacrine. Tacrine is an effective cholinesterase inhibitor and could probably be active in studies of Alzheimers's disease.
Synonyms	9-Amino-1,2,3,4-tetrahydroacridin-1-ol-d3 Maleate; 9-Amino-1,2,3,4-tetrahydro-1-acridinol-d3 Maleate; HP 029-d3 Maleate; Mentane-d3 Maleate; Velnacrine-d3 Maleate; 1-hydroxy tacrine-d3 Maleate; 9-Amino-1,2,3,4-tetrahydroacridin-1,2,2-d3-1-ol maleate; (±)-Velnacrine-1,2,2-d3 Maleate
IUPAC Name	9-amino-1,2,2-trideuterio-3,4-dihydroacridin-1-ol;(Z)-but-2-enedioic acid
Related CAS	118909-22-1 (unlabelled)
Canonical SMILES	C1CC(C2=C(C3=CC=CC=C3N=C2C1)N)O.C(=CC(=O)O)C(=O)O
InChI	InChI=1S/C13H14N2O.C4H4O4/c14-13-8-4-1-2-5-9(8)15-10-6-3-7-11(16)12(10)13;5-3(6)1-2-4(7)8/h1-2,4-5,11,16H,3,6-7H2,(H2,14,15);1-2H,(H,5,6)(H,7,8)/b;2-1-/i7D2,11D;
InChI Key	NEEKVKZFYBQFGT-DPIYXFFGSA-N
Purity	95% by HPLC; 98% atom D
Solubility	Soluble in DMSO (Slightly), Methanol (Slightly)
Appearance	White Solid
Storage	Store at -20°C

9-Amino-1,2,3,4-tetrahydroacridin-1-ol-[d3] Maleate, a versatile chemical compound, finds diverse applications across research and industry. Here are the key applications:

Neuroscience Research: Delving deep into neurological investigations, this compound serves as a potent acetylcholinesterase inhibitor, crucial for exploring conditions like Alzheimer’s disease. By elevating acetylcholine levels in the brain, it uncovers the intricate roles of cholinergic systems, shedding light on the brain’s biochemical and physiological intricacies.

Pharmacokinetics Studies: With its isotopic labeling, 9-Amino-1,2,3,4-tetrahydroacridin-1-ol-[d3] Maleate becomes a valuable asset in unraveling pharmacokinetics. It aids in meticulously tracking drug absorption, distribution, metabolism, and excretion (ADME), providing vital insights for drug development and optimizing dosing strategies in biological systems.

Drug Development: Pioneering the realm of neurodegenerative therapeutic advancements, this compound plays a pivotal role in crafting novel treatments. Researchers explore its structure-activity relationships to engineer potent and selective acetylcholinesterase inhibitors. These groundbreaking studies fuel the creation of drugs tailored to alleviate symptoms and halt the progression of debilitating diseases like Alzheimer’s.

Analytical Chemistry: Serving as a cornerstone in analytical laboratories, this compound functions as an internal standard for mass spectrometry assays. Its deuterated form enables precise quantification of compounds, distinguishing analytes from standards with accuracy. This application, crucial for high-precision measurements in clinical and research domains, ensures meticulous analysis in diverse settings.