CAS 1562067-05-3 Banoxantrone-[d12] - Isotope / BOC Sciences

General Information
Catalog: BLP-014033
CAS: 1562067-05-3
Molecular Formula: C22H16D12N4O6
Molecular Weight: 456.55

General Information

Catalog: BLP-014033

CAS: 1562067-05-3

Molecular Formula: C22H16D12N4O6

Molecular Weight: 456.55

Chemical Structure

Description	Banoxantrone-[d12] is the labelled analogue of Banoxantrone, which is a potent topoisomerase II inhibitor.
Synonyms	Banoxantrone-D12; 1,4-Bis[[2-(dimethyloxidoamino)ethyl]amino]-5,8-dihydroxy-9,10-anthracenedione-d12; AQ4N-d12
IUPAC Name	2-[[5,8-dihydroxy-4-[2-[oxido-bis(trideuteriomethyl)azaniumyl]ethylamino]-9,10-dioxoanthracen-1-yl]amino]-N,N-bis(trideuteriomethyl)ethanamine oxide
Related CAS	136470-65-0 (unlabelled) 252979-56-9 (unlabelled dihydrochloride)
Canonical SMILES	C[N+](C)(CCNC1=C2C(=C(C=C1)NCC[N+](C)(C)[O-])C(=O)C3=C(C=CC(=C3C2=O)O)O)[O-]
InChI	InChI=1S/C22H28N4O6/c1-25(2,31)11-9-23-13-5-6-14(24-10-12-26(3,4)32)18-17(13)21(29)19-15(27)7-8-16(28)20(19)22(18)30/h5-8,23-24,27-28H,9-12H2,1-4H3/i1D3,2D3,3D3,4D3
InChI Key	YZBAXVICWUUHGG-MGKWXGLJSA-N
Purity	≥97%
Solubility	Soluble in DMSO
Storage	Store in a cool and dry place (or refer to the Certificate of Analysis).

Banoxantrone-[d12], a deuterated analog of the chemotherapeutic agent banoxantrone, finds diverse applications in the field of medicine. Here are the key applications of Banoxantrone-[d12]:

Drug Metabolism Studies: A cornerstone of drug metabolism research, Banoxantrone-[d12] plays a pivotal role in unraveling the intricate pharmacokinetics and metabolic pathways of banoxantrone. Through the use of its deuterated analog, researchers can meticulously track and quantify the compound via mass spectrometry, shedding light on crucial aspects such as drug bioavailability, tissue distribution, and metabolic stability.

Cancer Research: In the realm of cancer studies, Banoxantrone-[d12] emerges as a vital tool for dissecting the mechanisms of action, resistance, and toxicity associated with banoxantrone in cancerous cells. Scientists leverage its properties to identify biomarkers and decipher cellular responses to treatment, paving the way for the development of more potent and less harmful cancer therapies.

Pharmaceutical Development: At the forefront of pharmaceutical innovation, Banoxantrone-[d12] plays a key role in refining and advancing formulations of banoxantrone. By harnessing the power of deuterium, researchers can optimize the drug’s pharmacokinetic profile, potentially leading to superior therapeutic outcomes. This breakthrough opens avenues for the creation of cutting-edge chemotherapeutic agents with heightened efficacy and safety profiles.

Analytical Chemistry: Embraced by the field of analytical chemistry, Banoxantrone-[d12] stands as a valuable asset for crafting and validating quantitative analytical methods. Its distinct isotopic signature elevates detection accuracy in mass spectrometry assays utilized for pharmacokinetic and bioequivalence studies. This precision supports regulatory adherence and quality assurance in the realm of drug manufacturing and testing, ensuring robust standards and meticulous scrutiny.