Citalopram-[d6] Hydrobromide

Citalopram-[d6] Hydrobromide, a deuterated variant of the selective serotonin reuptake inhibitor (SSRI) citalopram, finds its primary application in research settings. Here are some key applications:

Pharmacokinetic Studies: Delving into pharmacokinetics, scientists employ Citalopram-[d6] Hydrobromide extensively to probe the absorption, distribution, metabolism, and excretion (ADME) of citalopram. By leveraging the deuterated compound’s unique chemical fingerprint, precise tracking in mass spectrometry becomes achievable. This differentiation between exogenous and endogenous compounds is crucial for accurate analysis in ADME studies.

Drug Interaction Research: Unraveling the complexities of drug interactions, Citalopram-[d6] Hydrobromide serves as a cornerstone for investigating how various medications impact its metabolic pathways. As an internal standard in assays, this deuterated form ensures the consistency and reliability of results. These insights play a pivotal role in foreseeing adverse reactions and optimizing therapeutic strategies.

Metabolic Profiling: Shedding light on metabolic pathways, Citalopram-[d6] Hydrobromide aids in the precise identification and quantification of citalopram metabolites in biological specimens. Researchers leverage this deuterated compound to gain clearer insights into citalopram’s metabolic destiny. The data obtained from such analyses are vital for the development of safer and more efficacious antidepressant interventions.

Neuropharmacology: Within the realm of neuropharmacology, Citalopram-[d6] Hydrobromide emerges as a key tool for investigating the mechanisms of SSRIs on the central nervous system. Scientists tap into this compound to deepen their understanding of serotonin reuptake processes and the modulation of neurotransmitter levels. Such knowledge serves as a cornerstone for crafting novel antidepressants with heightened effectiveness and diminished side effects.