Cytidine-[ribose-2-13C]

Cytidine-[ribose-2-13C] is a stable isotope-labeled nucleoside with applications in various scientific fields. Here are some key applications of Cytidine-[ribose-2-13C]:

NMR Spectroscopy: Cytidine-[ribose-2-13C] is used in nuclear magnetic resonance (NMR) spectroscopy for structural analysis of RNA. The labeled carbon atom provides insights into ribose conformation and dynamics. Researchers can assess RNA folding and interactions, essential for understanding RNA function and structure.

Metabolic Flux Analysis: In metabolic studies, Cytidine-[ribose-2-13C] serves as a tracer to analyze the metabolic pathways of ribonucleotides. By tracing the incorporation of the 13C label, researchers can quantify the fluxes through different biochemical pathways. This helps in unraveling the complex metabolic networks and understanding nucleotide metabolism.

Stable Isotope Labeling Studies: Cytidine-[ribose-2-13C] is employed in stable isotope labeling studies to investigate nucleic acid metabolism. It helps in determining the rate of RNA synthesis and turnover in cells. This information is crucial for studying cell growth, differentiation, and response to external stimuli.

Pharmaceutical Research: In drug development and pharmacology, Cytidine-[ribose-2-13C] can be used to study the pharmacokinetics and dynamics of nucleotide analogs. The isotope label allows for precise tracking of these compounds in biological systems. This aids in assessing drug distribution, metabolism, and efficacy in therapeutic applications.