D-mannitol-[1,1'-d2]

D-mannitol-[11'-d2], a deuterium-labeled derivative of D-mannitol widely utilized in biochemical and clinical research, offers a spectrum of applications. Here are the key applications of D-mannitol-[11'-d2]:

Stable Isotope Labeling Studies: An indispensable tool in stable isotope labeling investigations, D-mannitol-[11'-d2] plays a pivotal role in tracking metabolic pathways. By integrating this labeled sugar into experiments, researchers can meticulously track its journey through metabolism using cutting-edge mass spectrometry techniques. This method yields invaluable insights into the intricate web of carbohydrate metabolism and nutrient utilization across diverse biological systems.

Pharmacokinetics: In the realm of pharmacokinetics, D-mannitol-[11'-d2] emerges as a fundamental tracer for comprehensively exploring the absorption, distribution, metabolism, and excretion (ADME) of pharmaceutical agents. Its stable isotope tagging enables precise quantification of mannitol concentrations within biological specimens, allowing for a thorough understanding of drug behavior. This application is paramount for unraveling the pharmacokinetic profiles and safety parameters of novel drug candidates, shaping the future of pharmaceutical research.

Renal Function Assessment: Stepping into clinical territory, D-mannitol-[11'-d2] assumes a critical role as a diagnostic asset for evaluating renal function in medical investigations. By administering this labeled compound and monitoring its excretion dynamics, healthcare professionals can assess key parameters such as glomerular filtration rate (GFR) and tubular function. This diagnostic approach aids in the identification and monitoring of renal disorders and conditions impacting kidney health, enhancing patient care through precise clinical evaluations.

Plant Physiology Research: Within the domain of plant physiology, the utility of D-mannitol-[11’-d2] shines through in studies exploring osmoregulation and osmotic stress responses. Researchers harness this labeled sugar to investigate the uptake and transport mechanisms in plants, deciphering how they maintain osmotic equilibrium amidst varying environmental challenges. This research avenue is pivotal for enhancing crop resilience against stressors like drought and salinity, offering insights into optimizing agricultural practices for sustainable food production in the face of changing climates.