D-ribose-[2,3,4,5,5'-d5]

D-ribose-[2,3,4,5,5'-d5], a labeled variant of D-ribose, finds extensive use in research and various applications. Here are the key applications:

Metabolic Flux Analysis: In the realm of metabolic flux analysis, D-ribose-[2,3,4,5,5'-d5] plays a pivotal role in delineating the intricate metabolic pathways within organisms. By incorporating this labeled sugar, researchers can meticulously track the flow and destiny of metabolites within cells. This understanding is paramount for unraveling the complexities of cellular metabolism and pinpointing potential metabolic bottlenecks.

NMR Spectroscopy: Delving into the realm of Nuclear Magnetic Resonance (NMR) spectroscopy, the deuterated iteration of ribose emerges as a key player. D-ribose-[2,3,4,5,5'-d5] takes center stage by facilitating the analysis of molecular structures and dynamics. Its substitution with deuterium yields clearer signals in NMR spectra, effectively reducing background noise. This enhancement enables researchers to conduct precise and detailed structural elucidation of nucleotides and other ribose-containing biomolecules.

Isotope Dilution Mass Spectrometry: Within the domain of isotope dilution mass spectrometry (IDMS), D-ribose-[2,3,4,5,5'-d5] assumes a critical role as an internal standard for the quantitative assessment of ribose and its derivatives. This labeled compound proves invaluable in rectifying variability and enhancing measurement accuracy. The application of this technique shines brightest in fields such as clinical diagnostics and biochemical research, where precision is paramount.

Drug Metabolism Studies: When it comes to drug metabolism studies, D-ribose-[2,3,4,5,5'-d5] emerges as a valuable asset for tracing the assimilation and breakdown of ribose-laden drugs within biological systems. By labeling the ribose moiety, scientists gain the ability to monitor the pharmacokinetics and metabolic journey of these compounds with precision. This insight serves as a cornerstone for refining drug designs and unraveling the intricate web of their metabolic profiles.