D-xylose-[5,5-d2]

D-xylose-[5,5-d2] is a stable isotope-labeled form of the pentose sugar xylose, frequently used in various research applications. Here are some key applications of D-xylose-[5,5-d2]:

Metabolic Tracing: D-xylose-[5,5-d2] is utilized in metabolic studies to trace the xylose metabolic pathway in organisms. By incorporating this labeled sugar into metabolic assays, researchers can monitor the incorporation and transformation of xylose with high precision. This aids in understanding carbohydrate metabolism and identifying key metabolic intermediates.

Gut Permeability Tests: D-xylose-[5,5-d2] can be used in clinical research to assess intestinal absorption and gut permeability. Patients ingest the labeled sugar, and the subsequent measurement of its concentration in urine or blood serves as an indicator of gut function. This test helps in diagnosing conditions like malabsorption syndromes and celiac disease.

Biofuel Research: In the development of biofuels, D-xylose-[5,5-d2] is employed to study the fermentation processes of xylose-utilizing microorganisms. By tracking the utilization of labeled xylose, researchers can optimize fermentation conditions and engineer microbial strains for improved biofuel production. This contributes to the efficient conversion of biomass into renewable energy sources.

Pharmacokinetics: D-xylose-[5,5-d2] can be applied in pharmacokinetic studies to investigate the absorption, distribution, metabolism, and excretion of drugs. When administered alongside drugs, the labeled sugar helps in elucidating how a drug interacts with biological systems. This information is valuable for drug formulation and understanding how different physiological conditions affect drug efficacy.