D-glucitol-[6,6'-d2]

D-glucitol-[6,6'-d2], known as deuterated sorbitol, is a stable isotope-labeled compound with diverse applications in scientific research and industry. Here are the key applications of D-glucitol-[6,6'-d2]:

Metabolic Tracing: Acting as a tracer in metabolic studies, D-glucitol-[6,6'-d2] illuminates carbohydrate metabolism pathways. Researchers employ this labeled compound to trace its conversion into other metabolites, shedding light on specific biochemical pathways. This tool proves invaluable in deciphering conditions like diabetes and exploring novel therapeutic avenues.

Stable Isotope Dilution Analysis: Within the realm of analytical chemistry, D-glucitol-[6,6'-d2] takes center stage as an internal standard for stable isotope dilution assays. This technique heightens the precision and accuracy of quantitative measurements, compensating for matrix effects and instrumental fluctuations. Widely embraced, it facilitates the determination of sugar and polyol concentrations in intricate biological samples.

Pharmacokinetics: A cornerstone in pharmacokinetic assessments, D-glucitol-[6,6'-d2] plays a pivotal role in evaluating drug absorption, distribution, metabolism, and excretion. By incorporating deuterium-labeled drugs or metabolites, scientists probe the body's processing mechanisms. This data proves instrumental in refining drug formulations and dosing strategies, optimizing patient outcomes.

Structural Biology: In the realm of structural biology, D-glucitol-[6,6'-d2] emerges as a potent tool for neutron scattering investigations into macromolecular structures. Deuterium labeling enhances contrast in neutron scattering, enabling nuanced analyses of molecular architectures and interactions. This cutting-edge technique is pivotal in unraveling the intricacies of complex biomolecular assemblies, pushing the boundaries of structural biology exploration.