D-Glucose-[4-13C]

D-Glucose-[4-13C], a stable isotope-labeled variant of glucose, finds widespread use in scientific research across various disciplines. Here are the key applications of D-Glucose-[4-13C]:

Metabolic Flux Analysis: Employing D-Glucose-[4-13C], researchers engage in metabolic flux analysis to quantify the flow of carbon molecules through intricate metabolic pathways. By tracking the incorporation of the 13C label into metabolic intermediates and end-products, scientists gain profound insights into cellular metabolism. This detailed analysis unveils the mechanisms behind energy production, biosynthetic processes, and metabolic regulation within cellular environments.

Glucose Uptake Studies: In the realm of biomedical research, D-Glucose-[4-13C] serves as a pivotal tool for measuring glucose uptake and utilization in various tissues and organs. By monitoring the journey of labeled glucose, scientists delve into how different conditions, such as disease states or drug interventions, impact glucose metabolism. This investigative approach holds particular significance in studies related to diabetes, cancer, and metabolic disorders, shedding light on the intricate workings of cellular metabolism.

NMR Spectroscopy: The utilization of D-Glucose-[4-13C] in nuclear magnetic resonance (NMR) spectroscopy facilitates in-depth studies of carbohydrate structure and dynamics. The presence of the 13C label enhances the resolution and sensitivity of NMR signals, enabling researchers to conduct detailed structural analysis. This information aids in comprehending the conformational properties and interactions of glucose in both solution and biological systems, providing valuable insights into molecular structures and dynamics.