DL-Cysteine-[1-13C]

DL-Cysteine-[1-13C] is a stable isotope-labeled amino acid used extensively in biochemical and medical research. Here are some key applications of DL-Cysteine-[1-13C]:

Metabolic Flux Analysis: DL-Cysteine-[1-13C] is employed in metabolic flux analysis to trace sulfur metabolism pathways in cells and organisms. By monitoring the incorporation of the labeled cysteine into downstream metabolites, researchers can gain insights into the dynamics of metabolic networks. This data is crucial for understanding cellular metabolism and identifying potential targets for metabolic engineering.

Protein Structure and Function Studies: The use of DL-Cysteine-[1-13C] allows scientists to investigate protein dynamics, folding, and interactions through techniques such as Nuclear Magnetic Resonance (NMR) spectroscopy. The labeled cysteine provides specific isotopic signals that can be tracked, offering detailed structural information. This aids in elucidating the role of cysteine residues in protein function and stability.

Biomarker Research: DL-Cysteine-[1-13C] is utilized in clinical research to study biomarkers associated with oxidative stress and disease states. By tracking the conversion of labeled cysteine into other sulfur-containing compounds, researchers can monitor changes in metabolic pathways that are indicative of pathological conditions. This application is valuable for developing diagnostic tools and understanding disease mechanisms.

Pharmacokinetics: In drug development, DL-Cysteine-[1-13C] can be used to study the pharmacokinetics of cysteine-containing drugs and compounds. By tracing the labeled cysteine in biological systems, scientists can determine the absorption, distribution, metabolism, and excretion (ADME) profiles of these compounds. This information is critical for assessing drug efficacy and safety.