DL-Glutamic acid-[1-13C]

DL-Glutamic acid-[1-13C], a stable isotope-labeled compound, finds diverse applications in research. Here are key applications presented with high perplexity and burstiness:

Metabolic Flux Analysis: DL-Glutamic acid-[1-13C] plays a pivotal role in metabolic studies, allowing researchers to map the intricate pathways of carbon within cells. By monitoring the labeled carbon, scientists unravel the flux of metabolites through vital metabolic pathways like the tricarboxylic acid cycle. This knowledge is essential for deciphering cellular energy generation and biosynthetic processes.

Protein Dynamics Studies: In the realm of protein research, DL-Glutamic acid-[1-13C] acts as a crucial precursor for isotopic labeling of proteins, enabling in-depth investigations into protein structure and dynamics using nuclear magnetic resonance (NMR) spectroscopy. The incorporation of the ^13C label simplifies NMR spectra, enhancing sensitivity and facilitating detailed analyses of protein folding, interactions, and conformational changes.

Environmental Tracing: DL-Glutamic acid-[1-13C] serves as a powerful tool in environmental studies, offering insights into nutrient cycling and carbon flow within ecosystems. This labeled compound can be introduced into soil or aquatic systems to track its assimilation into microbial biomass and other organic materials. Such studies shed light on ecosystem productivity and the functions of various organisms in biogeochemical cycles.

Clinical Research: In clinical applications, DL-Glutamic acid-[1-13C] is utilized for diagnostic purposes, particularly in non-invasive breath tests to evaluate gastrointestinal function. The metabolism of this compound releases labeled carbon dioxide, which can be detected in breath samples. This non-invasive method aids in diagnosing conditions linked to malabsorption and gastric acid secretion.