Flibanserin-[d4] hydrochloride - Isotope / BOC Sciences

General Information
Catalog: BLP-013929
Molecular Formula: C20H18D4ClF3N4O
Molecular Weight: 430.89

General Information

Catalog: BLP-013929

Molecular Formula: C20H18D4ClF3N4O

Molecular Weight: 430.89

Chemical Structure

Description	Flibanserin-[d4] HCl is an isotope labelled derivative of Flibanserin. Flibanserin is used for the treatment of pre-menopausal women with hypoactive sexual desire disorder.
Synonyms	1-(2-(4-(3-(Trifluoromethyl)phenyl)piperazin-1-yl)ethyl)-1H-benzo[d]imidazol-2(3H)-one-d4 hydrochloride
Related CAS	147359-76-0 (unlabelled)
Canonical SMILES	O=C1N(C([2H])([2H])C([2H])([2H])N2CCN(C3=CC(C(F)(F)F)=CC=C3)CC2)C4=CC=CC=C4N1.Cl
InChI	InChI=1S/C20H21F3N4O.ClH/c21-20(22,23)15-4-3-5-16(14-15)26-11-8-25(9-12-26)10-13-27-18-7-2-1-6-17(18)24-19(27)28;/h1-7,14H,8-13H2,(H,24,28);1H/i10D2,13D2;
InChI Key	XGAGFLQFMFCIHZ-BMJFOILFSA-N
Purity	95% by HPLC; 99% atom D
Solubility	Soluble in DMSO (Slightly), Methanol (Slightly)
Storage	Store at -20°C

Flibanserin-[d4] hydrochloride, a deuterium-labeled analogue of flibanserin, exemplifies versatility with its primary applications spanning various research domains. Here are the key applications of Flibanserin-[d4] hydrochloride:

Pharmacokinetic Studies: Interwoven within the intricate fabric of pharmacokinetic inquiries, Flibanserin-[d4] hydrochloride assumes a pivotal role in unraveling the complexities of drug absorption, distribution, metabolism, and excretion (ADME) of flibanserin. Its deuterium labeling enables meticulous tracing within biological systems through mass spectrometry, facilitating the generation of precise and critical data on drug behavior crucial for safety and efficacy evaluations.

Drug Metabolism Research: By harnessing Flibanserin-[d4] hydrochloride, researchers embark on a voyage to explore the metabolic pathways of flibanserin, identifying its diverse metabolites and unraveling their potential pharmacological or toxicological impacts. The stable isotope labeling assists in discriminating between the parent compound and its metabolites, providing vital information for the development of safer and more efficient drug formulations.

Quality Control in Manufacturing: Positioned within the intricate tapestry of pharmaceutical manufacturing, Flibanserin-[d4] hydrochloride assumes the mantle of an internal standard for quality control and assurance purposes. It plays a critical role in maintaining consistency and precision in the analytical methods used to quantify flibanserin in both bulk drug substances and finished pharmaceutical products, ensuring adherence to purity and potency specifications.

Neuropharmacology Research: Nestled in the realm of neuropharmacology, Flibanserin-[d4] hydrochloride emerges as a prominent player in unraveling the mechanism of action of the drug within the brain and its influence on neurotransmitter systems. Through the utilization of the deuterium-labeled analogue, researchers can meticulously assess the interactions of flibanserin with diverse brain receptors and pathways, fostering a deeper understanding of its therapeutic capabilities and potential side effects.