(±)-Flurbiprofen-[d5]

(±)-Flurbiprofen-[d5], a deuterium-labeled rendition of flurbiprofen, a nonsteroidal anti-inflammatory drug (NSAID), is primarily utilized in research settings for its distinctive characteristics. Here are the key applications of (±)-Flurbiprofen-[d5]:

Pharmacokinetic Studies: Employing (±)-Flurbiprofen-[d5] in pharmacokinetic investigations enables the monitoring of the drug’s absorption, distribution, metabolism, and excretion within the body. The deuterium label facilitates precise and accurate measurements using mass spectrometry, aiding in comprehending the drug’s behavior and refining dosing strategies.

Metabolic Pathway Elucidation: Researchers utilize (±)-Flurbiprofen-[d5] to explore the metabolic pathways and identify metabolites in biological samples. The deuterium labeling simplifies the differentiation between the parent drug and its metabolites, providing critical insights into drug metabolism and potential interactions.

Isotope Dilution Analysis: (±)-Flurbiprofen-[d5] serves as an internal standard in isotope dilution mass spectrometry (IDMS), enhancing the accuracy and precision of quantitative analyses of flurbiprofen in complex biological matrices. By leveraging the labeled compound as a reference, researchers can achieve robust analytical outcomes, advancing the reliability of their results.

Drug Interaction Studies: The deuterium-labeled flurbiprofen proves invaluable for investigating drug-drug interactions, enabling scientists to explore how flurbiprofen is metabolized in the presence of other drugs without interference. This application is vital for evaluating the safety and efficacy of combination therapies, shedding light on potential interactions that could influence treatment outcomes.