Stable isotope labeling allows researchers to study metabolic pathways in vivo in a safe manner.
Stable isotope-labeled compounds are used as environmental pollutant standards for the detection of air, water, soil, sediment and food.
In addition to treating various diseases, isotopes are used for imaging, diagnosis, and newborn screening.
Small molecule compounds labeled with stable isotopes can be used as chemical reference for chemical identification, qualitative, quantitative, detection, etc. Various types of NMR solvents can be used to study the structure, reaction mechanism and reaction kinetics of compounds.
Stable isotope labeling allows researchers to study metabolic pathways in vivo in a safe manner.
Stable isotope-labeled compounds are used as environmental pollutant standards for the detection of air, water, soil, sediment and food.
General Information |
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Catalog: BLP-009289 |
CAS: 7325-16-8 |
Molecular Formula: C3H5D3O3 |
Molecular Weight: 95.11 |
Chemical Structure |
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Description | Glycer(ol-[d3]) is the labelled analogue of Glycerol. Glycerol can be used as an emollient, solvent, sweetening agent, in pharmaceutical formulations, cosmetics, foodstuffs and toiletries. |
Synonyms | 1,2,3-Propanetriol-d3(9CI) |
IUPAC Name | 1,2,3-trideuteriooxypropane |
Related CAS | 56-81-5 (unlabelled) |
Isomeric SMILES | [2H]OCC(CO[2H])O[2H] |
Canonical SMILES | C(C(CO)O)O |
InChI | InChI=1S/C3H8O3/c4-1-3(6)2-5/h3-6H,1-2H2/i4D,5D,6D |
InChI Key | PEDCQBHIVMGVHV-WVALGTIDSA-N |
Boiling Point | 182°C (lit.) |
Melting Point | 20°C (lit.) |
Purity | 99% by CP; 99% atom D |
Density | 1.302 g/cm3 |
Glycerol-d3, a deuterated variant of glycerol, finds extensive utility across diverse fields of research and industry. Here are four pivotal applications of Glycerol-d3 presented with a high degree of perplexity and burstiness:
Metabolic Studies: Acting as a stable isotope tracer in metabolic investigations, Glycerol-d3 offers a window into the intricate pathways of living organisms. By meticulously tracing the assimilation and metamorphosis of Glycerol-d3 within biological milieus, researchers unearth valuable insights into metabolic flux and the orchestration of pathways like glycolysis and lipid synthesis. This investigative approach affords a nuanced comprehension of metabolic aberrations and informs the formulation of therapeutic interventions.
Biochemical Research: Delving into enzyme mechanics and reaction kinetics, Glycerol-d3 serves as a beacon in biochemical inquiries. The deuterium tagging affords unique perspectives on kinetic isotope effects, pivotal in unravelling enzyme-mediated reactions encompassing glycerol. This application not only bolsters enzyme manipulation practices but also fuels the design of inhibitors with therapeutic implications, forging new frontiers in drug development.
NMR Spectroscopy: A cornerstone in nuclear magnetic resonance (NMR) spectroscopy, Glycerol-d3 is a stalwart tool for delving into the realm of biomolecules. The presence of deuterium acts as a shield, quelling background noise and sharpening resolution in NMR spectra. This sharpened lens empowers researchers to glean intricate structural insights into macromolecules like proteins and nucleic acids, unveiling the cryptic architecture of biological components.
Pharmaceutical Development: Within the pharmaceutical domain, Glycerol-d3 emerges as a linchpin in unraveling the pharmacokinetics of glycerol-laden formulations. Leveraging deuterated glycerol, scientists navigate the labyrinthine pathways of drug absorption, distribution, metabolism, and excretion with surgical precision.
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