Glycine-[1-13C,2,2-d2]

Glycine-[1-13C,2,2-d2], an isotopically labeled amino acid utilized in various scientific investigations, holds significant value in metabolic research and structural biology. Here are key applications of Glycine-[1-13C,2,2-d2] presented with high perplexity and burstiness:

Metabolic Tracing: Serving as a versatile tracer in metabolic studies, Glycine-[1-13C,2,2-d2] enables researchers to meticulously trace carbon fluxes within cellular systems. By integrating this labeled glycine into metabolic pathways, scientists can precisely delineate biochemical routes and measure metabolic rates with exceptional accuracy. This method sheds light on metabolic perturbations linked to diseases like cancer and metabolic disorders, offering insights into potential therapeutic strategies.

NMR Spectroscopy: The isotopic labeling in Glycine-[1-13C,2,2-d2] plays a pivotal role in nuclear magnetic resonance (NMR) spectroscopy investigations, elevating the sensitivity and resolution of NMR signals. This enhancement aids in detailed structural analyses of proteins and nucleic acids, allowing scientists to explore conformational dynamics and interactions of biomolecules. Such insights not only inform drug design but also deepen our understanding of molecular mechanisms underpinning biological processes.

Protein Synthesis Studies: Glycine-[1-13C,2,2-d2] is a valuable tool for probing protein synthesis and degradation pathways across diverse biological systems. By incorporating into newly synthesized proteins, it offers a window into protein turnover rates and folding kinetics. This information is crucial for unraveling cellular homeostasis, aging processes, and cellular responses to external stressors, providing a nuanced perspective on cellular dynamics.

Biochemical Pathway Analysis: In the realm of biochemical studies, Glycine-[1-13C,2,2-d2] aids in mapping intricate amino acid metabolic pathways, enhancing our understanding of cellular metabolism. Researchers leverage this isotopically labeled amino acid to track the synthesis and breakdown of glycine and related metabolites in cellular and tissue environments. These insights contribute significantly to our knowledge of amino acid metabolism, shedding light on its implications for health and disease.