Boc-Gly-OH-[1-13C]

Boc-Gly-OH-[1-13C] is a Boc-protected glycine derivative containing a carbon-13 isotope. Its applications in bioscience are essential for various research purposes. Here are some key applications of Boc-Gly-OH-[1-13C]:

NMR Spectroscopy: Boc-Gly-OH-[1-13C] is commonly used in nuclear magnetic resonance (NMR) spectroscopy to study protein structures. The carbon-13 isotope acts as a stable and detectable marker, providing detailed information about the molecular environment of glycine residues in proteins. This helps researchers understand protein folding, dynamics, and interactions.

Metabolic Flux Analysis: In metabolic studies, Boc-Gly-OH-[1-13C] is employed to trace metabolic pathways by monitoring the incorporation of the carbon-13 atom into metabolic intermediates. This approach provides insights into metabolic activity and flux, enabling optimization of metabolic engineering strategies. It's particularly useful in understanding how cells process and utilize nutrients.

Synthetic Chemistry: Boc-Gly-OH-[1-13C] is valuable in synthetic organic chemistry for the preparation of isotopically labeled peptides and other molecules. The Boc-protected glycine serves as a building block in peptide synthesis, and the carbon-13 isotope allows for precise tracking and characterization of molecular transformations. This is crucial for drug development and structural biology studies.

Pharmacokinetics Studies: Boc-Gly-OH-[1-13C] can be used in pharmacokinetic studies to label drugs and track their absorption, distribution, metabolism, and excretion in the body. The carbon-13 isotope provides a non-radioactive tracer, making it a safer alternative for human and animal studies. This facilitates the development of safer and more effective therapeutic compounds.