JWH-122 4-Hydroxypentyl metabolite-[d5] (indole-[d5])

JWH-122 4-Hydroxypentyl metabolite-[d5], a labeled synthetic cannabinoid metabolite utilized for scientific research, offers a multitude of applications. Here are the key applications:

Analytical Chemistry: Essential in forensic toxicology, this labeled metabolite plays a crucial role in developing and validating analytical methods for detecting and quantifying synthetic cannabinoids in biological samples. By utilizing it as an internal standard, it enhances the accuracy and reliability of mass spectrometry analyses. This significance lies in its ability to identify drug use and ensure compliance with regulations through meticulous monitoring.

Pharmacokinetic Studies: Researchers leverage this compound in pharmacokinetic studies to trace the absorption, distribution, metabolism, and excretion (ADME) of JWH-122 within the body. Its deuterated form aids in distinguishing the metabolite from endogenous substances and other cannabinoids, offering invaluable insights into the drug’s behavior and its potential impact on human health. This information is fundamental in deciphering the complex interactions of the drug within biological systems.

Metabolism Research: Serving as a vital tool for studying metabolic pathways and enzymatic activities involved in the biotransformation of synthetic cannabinoids, the labeled metabolite enables researchers to explore its interactions with liver enzymes. By identifying metabolic intermediates and end products, scientists can predict the metabolic destiny of new synthetic cannabinoids, shedding light on their potential effects on biological systems. This knowledge is pivotal for advancing our understanding of drug metabolism and its implications for drug development and safety.

Toxicology: Employed in toxicological research, JWH-122 4-Hydroxypentyl metabolite-[d5] is instrumental in assessing the potential health risks and toxic effects linked to synthetic cannabinoid usage. It aids in pinpointing biomarkers of exposure and toxicity, laying the groundwork for the establishment of safety guidelines and therapeutic interventions for individuals experiencing synthetic cannabinoid intoxication. This application underscores the importance of comprehensive toxicological assessments in safeguarding public health and guiding regulatory decisions.