L-mannose-[1-13C]

L-mannose-[1-13C] stands as a pivotal stable isotope-labeled mannose variant with diverse applications in scientific investigations. Here are the significant applications of L-mannose-[1-13C]:

Metabolic Flux Analysis: In the domain of metabolic flux analysis (MFA), L-mannose-[1-13C] emerges as a key player, facilitating the tracing of carbohydrate metabolism. By integrating this isotopically labeled sugar into cellular systems, researchers gain the ability to track carbon flow throughout metabolic pathways. This invaluable tool sheds light on intricate cellular metabolism dynamics, aiding in the optimization of metabolic engineering endeavors and the comprehension of various disease states.

Glycoprotein Research: Delving into the realms of glycoprotein biosynthesis and turnover, L-mannose-[1-13C] serves as a cornerstone for scientific inquiry. By monitoring the integration of this labeled sugar into glycoproteins, researchers unlock insights into the complexities of protein glycosylation dynamics. This study is paramount for unraveling diseases associated with glycoprotein metabolism and advancing the development of glycoprotein-based therapeutics.

Isotope Ratio Mass Spectrometry (IRMS): Enter the world of Isotope Ratio Mass Spectrometry (IRMS), where L-mannose-[1-13C] reigns supreme in enhancing the precision of isotope ratio determinations. This application holds critical importance in fields like environmental studies, where pinpoint accuracy in isotopic measurements is imperative for tracking biological and ecological processes. The utilization of labeled mannose elevates the sensitivity and specificity of these analyses, pushing the boundaries of scientific inquiry.

Diagnostic Biomarker Development: Witness the transformative potential of L-mannose-[1-13C] in the realm of diagnostic biomarker development for metabolic disorders. By unraveling the metabolic destiny of this labeled compound within biological samples, researchers uncover biomarkers indicative of diseases such as diabetes or congenital disorders of glycosylation. This pioneering approach aids in the early detection and continuous monitoring of disease progression, revolutionizing diagnostic procedures in the field.