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L-Arginine-[5-13C,4,4,5,5-d4]

General Information
Catalog: BLP-004502
Molecular Formula: C5[13C]H10D4N4O2
Molecular Weight: 179.22
Chemical Structure
L-Arginine-[5-13C,4,4,5,5-d4]
Description L-Arginine-[5-13C,4,4,5,5-d4] is the labelled analogue of L-Arginine, which is intended for use as an internal standard for the quantification of ledipasvir by GC-or LC-MS.
Synonyms L-Arginine-5-13C,4,4,5,5-d4; S-2-Amino-5-guanidinopentanoic acid-5-13C,4,4,5,5-d4; L-Arginine-13C,d4; L-(+)-Arginine-13C,d4; H-Arg-OH-13C,d4
IUPAC Name (2S)-2-amino-4,4,5,5-tetradeuterio-5-(diaminomethylideneamino)(5-13C)pentanoic acid
Related CAS 74-79-3 (unlabelled)
Canonical SMILES C(CC(C(=O)O)N)CN=C(N)N
InChI InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/t4-/m0/s1/i1D2,3+1D2
InChI Key ODKSFYDXXFIFQN-BRCPYFOBSA-N
Melting Point 222 °C (dec.)
Purity 98% by CP; 99% atom 13C; 97% atom D

L-Arginine-[5-13C,4,4,5,5-d4], a stable isotope-labeled amino acid, finds diverse applications in scientific and clinical realms. Here are key applications of L-Arginine-[5-13C,4,4,5,5-d4] presented with high perplexity and burstiness:

Metabolic Tracing: A potent tool in metabolic investigations, L-Arginine-[5-13C,4,4,5,5-d4] is instrumental in tracing the intricate pathways and destinies of arginine within biological systems. By harnessing this labeled compound, scientists can meticulously quantify the rates of arginine metabolism and its transformation into other metabolites. This knowledge is paramount for unraveling the enigmatic world of amino acid metabolism, shedding light on its complexities in both health and disease scenarios.

Protein Turnover Studies: Within the realm of protein research, L-Arginine-[5-13C,4,4,5,5-d4] emerges as a key player capable of being assimilated into proteins to scrutinize the dynamics of protein synthesis and breakdown. By meticulously tracking the isotope as it integrates into newly-formed proteins, researchers can dissect the intricate dance of protein turnover in diverse physiological and pathological settings. This information is indispensable for grasping the equilibrium of protein structures and the vexing puzzle of muscle wasting disorders.

Nutritional Research: In the arena of nutritional exploration, L-Arginine-[5-13C,4,4,5,5-d4] plays a pivotal role in dissecting nutrient metabolism and evaluating the efficacy of dietary supplements. Through vigilant monitoring of its assimilation and metabolism, scientists can gauge the impact of arginine supplementation on nitric oxide production and cardiovascular well-being. This understanding serves as a cornerstone for crafting dietary interventions aimed at enhancing health and thwarting the onset of diseases.

Clinical Diagnostics: In the sphere of clinical diagnostics, the labeled arginine serves as a beacon for assessing liver functionality and detecting urea cycle disorders. By scrutinizing the conversion rates of L-Arginine-[5-13C,4,4,5,5-d4] within the body, healthcare practitioners can glean valuable insights into metabolic irregularities. This knowledge serves as a compass, guiding the diagnosis and treatment strategies for a spectrum of liver-associated and metabolic afflictions.

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