L-Asparagine-[1,4-13C2,alpha-15N] monohydrate

L-Asparagine-[1,4-13C2,alpha-15N] monohydrate is an isotopically-labeled amino acid essential for advanced scientific research. Here are some key applications of L-Asparagine-[1,4-13C2,alpha-15N] monohydrate:

Metabolic Studies: L-Asparagine-[1,4-13C2,alpha-15N] monohydrate is used in metabolic flux analysis to study amino acid metabolism in cells. By tracing the incorporation of the labeled atoms through metabolic pathways, researchers can measure fluxes and metabolic responses to different conditions. This helps in understanding metabolic dynamics and identifying metabolic disorders.

Protein Structure and Function: The isotopic labeling of L-Asparagine allows for detailed studies of protein structure and function using Nuclear Magnetic Resonance (NMR) spectroscopy. Researchers can investigate protein folding dynamics and interactions with other molecules. This application is crucial for drug design and understanding disease-related protein dysfunction.

Nutritional Research: In nutritional studies, L-Asparagine-[1,4-13C2,alpha-15N] monohydrate can be used to trace amino acid absorption, distribution, and incorporation into proteins in vivo. This helps in assessing the bioavailability and utilization of dietary amino acids. Insights gained can inform dietary recommendations and interventions for various populations.

Biomarker Discovery: L-Asparagine-[1,4-13C2,alpha-15N] monohydrate can be utilized in biomarker discovery research, particularly in cancer metabolism studies. By examining how cancer cells metabolize labeled asparagine, researchers can identify potential metabolic biomarkers for early detection and therapeutic targeting. This can lead to the development of more effective diagnostic and treatment strategies.