L-Aspartic acid-[2-13C]

L-Aspartic acid-[2-13C], a stable isotope-labeled compound, finds extensive utility across diverse scientific domains. Here are the key applications of L-Aspartic acid-[2-13C]:

Metabolic Tracing: Delving into metabolic tracing studies, L-Aspartic acid-[2-13C] serves as a crucial tool for unraveling intricate metabolic pathways and fluxes within cellular ecosystems. By meticulously tracking the incorporation of labeled carbon into metabolic intermediates, researchers unearth profound insights into cellular metabolism. This application stands as a cornerstone for deciphering diseases linked to metabolic dysregulation and for refining industrial bioprocesses with precision.

Proteomics Research: Within the domain of proteomics, L-Aspartic acid-[2-13C] emerges as a pivotal player in probing protein synthesis dynamics and turnover phenomena. Through integration of the labeled amino acid into newly synthesized proteins, researchers embark on a quantitative analysis of protein dynamics using cutting-edge mass spectrometry techniques. This methodology aids in identifying nuanced changes in protein expression levels under diverse physiological contexts or in response to therapeutic interventions.

Structural Biology: Navigating the intricate realms of structural biology, L-Aspartic acid-[2-13C] unveils its potential in NMR spectroscopy applications aimed at unraveling protein structure intricacies and dynamic behaviors. The 13C label acts as a versatile probe, shedding light on the local nuances of aspartic acid residues within proteins. This detailed information forms the bedrock for deciphering protein folding processes, intermolecular interactions, and functional attributes at the molecular scale, driving forward our comprehension of biological complexities.

Drug Metabolism Studies: In the realm of pharmacokinetics, L-Aspartic acid-[2-13C] stands at the forefront as a vital tracer, facilitating in-depth investigations into drug and xenobiotic metabolism dynamics. By scrutinizing the metabolic fate and excretion patterns of the labeled compound within biological milieus, researchers gain crucial insights into the pharmacodynamics and toxicity profiles of therapeutic agents. This pivotal knowledge streamlines drug design processes.