L-Aspartic acid-[3,4-13C2]

L-Aspartic acid-[3,4-13C2] is a stable isotope-labeled compound used in various scientific research applications. Here are some key applications of L-Aspartic acid-[3,4-13C2]:

Metabolic Flux Analysis: L-Aspartic acid-[3,4-13C2] is used in metabolic flux analysis to trace metabolic pathways and measure the flow of metabolites through primary and secondary metabolic networks. By incorporating this labeled compound into biological systems, researchers can quantify its conversion into other metabolites. This helps in understanding cellular metabolism and optimizing metabolic engineering strategies.

Protein Structure and Dynamics: In NMR spectroscopy, L-Aspartic acid-[3,4-13C2] aids in investigating protein structure and dynamics. The incorporation of the 13C labels into proteins provides detailed insights into the structural arrangement and movement within the protein molecules. Researchers can thus gain a better understanding of protein function, folding, and interactions.

Neuroscience Research: L-Aspartic acid-[3,4-13C2] is used to study excitatory neurotransmission and amino acid metabolism in the brain. By using this isotope-labeled compound, researchers can track the metabolism of aspartic acid in neuronal tissues. This application is critical for exploring neurological disorders and the role of excitatory neurotransmitters in brain function.

Pharmaceutical Development: In drug metabolism studies, L-Aspartic acid-[3,4-13C2] is employed to assess the metabolic stability and degradation pathways of new therapeutic agents. Researchers can use this compound to trace aspartate-related metabolic routes, thereby providing information critical to drug design and safety evaluation. This application assists in developing drugs with favorable pharmacokinetic properties.