L-citrulline-[ureido-13C,3,3,4-d3]

L-citrulline-[ureido-13C,3,3,4-d3], a labeled amino acid extensively utilized in metabolic and physiological research, plays a pivotal role in various applications:

Metabolic Pathway Tracing: Delving into the intricate world of metabolic pathways, L-citrulline-[ureido-13C,3,3,4-d3] serves as a valuable tool for tracing nitrogen metabolism and the urea cycle. By introducing this labeled amino acid, researchers can meticulously monitor its integration and metamorphosis within diverse metabolic processes. This approach unveils profound insights into the intricate utilization and processing of amino acids and nitrogen within the human body.

Clinical Nutrition Research: In the realm of clinical nutrition, L-citrulline-[ureido-13C,3,3,4-d3] emerges as a key player in unraveling the mysteries surrounding citrulline's involvement in protein synthesis and overall nitrogen balance. Researchers leverage this labeled compound to explore the kinetic parameters of citrulline and its conversion to arginine and other metabolites. Understanding these complex pathways is critical for devising effective nutritional strategies to combat conditions like malnutrition and muscle wasting.

Pharmacokinetics and Pharmacodynamics: The realm of pharmacokinetic and pharmacodynamic studies finds immense value in the usage of L-citrulline-[ureido-13C,3,3,4-d3]. This labeled amino acid sheds light on the absorption, distribution, metabolism, and excretion of L-citrulline, enabling researchers to delineate the bioavailability and intricate metabolic profiles of citrulline-based supplements or medications. This detailed information serves as a cornerstone for the development of safe and potent therapeutic interventions.

Cardiovascular Research: Within the domain of cardiovascular studies, L-citrulline-[ureido-13C,3,3,4-d3] takes center stage in elucidating its impact on nitric oxide production and endothelial function. Leveraging the distinctive properties of the labeled isotope, researchers can precisely measure nitric oxide synthesis originating from citrulline. This research is instrumental in exploring innovative therapeutic strategies for enhancing vascular health and managing hypertension effectively.