Name: L-citrulline-[ureido-15N]
Brand: BOC Sciences
Rating: 5 (1 reviews)

General Information

Catalog: BLP-009005

Molecular Formula: C6H13N2[15N]O3

Molecular Weight: 176.18

Chemical Structure

Description	L-citrulline-[ureido-15N] is a labelled L-Citrulline. Citrulline is an α-amino acid. It is an intermediate in the urea cycle as well as a byproduct of the enzymatic production of nitric oxide from arginine.
IUPAC Name	(S)-2-amino-5-(ureido-15N)pentanoic acid
Related CAS	372-75-8 (unlabelled)
Canonical SMILES	C(CC(C(=O)O)N)CNC(=O)N
InChI	InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1/i8+1
InChI Key	RHGKLRLOHDJJDR-PYVFBUQJSA-N
Purity	98% by CP; 98% atom 15N
Solubility	Soluble in Water
Appearance	White to Pale Yellow Solid
Storage	Store at -20°C

L-citrulline-[ureido-15N] is a labeled amino acid used in various biochemical and medical research applications. Here are some key applications of L-citrulline-[ureido-15N]:

Metabolic Pathway Tracing: L-citrulline-[ureido-15N] is used as a tracer in metabolic studies to investigate the urea cycle and nitric oxide synthesis pathways. By tracking the incorporation of the 15N isotope, researchers can gain insights into the dynamics of nitrogen metabolism in different tissues. This application is crucial for understanding metabolic disorders and developing nutritional strategies.

Protein Turnover Studies: In protein metabolism research, L-citrulline-[ureido-15N] helps in studying protein synthesis and degradation rates in living organisms. Researchers can administer this labeled compound and subsequently analyze its incorporation into proteins over time. This technique is valuable for examining muscle growth, aging, and response to different dietary or pharmacological interventions.

Pharmacokinetic Studies: L-citrulline-[ureido-15N] plays a role in pharmacokinetic research to analyze drug metabolism and bioavailability. When used in conjunction with other labeled compounds, it helps to map the absorption, distribution, metabolism, and excretion (ADME) of pharmaceuticals. This information is essential for optimizing drug formulations and improving therapeutic efficacy.