L-Glutamine-[4-13C]

L-Glutamine-[4-13C] a stable isotope-labeled analogue of L-glutamine finds wide application in scientific research. Explore the diverse uses of L-Glutamine-[4-13C] with elevated perplexity and burstiness:

Metabolic Flux Analysis: Delve into the intricate pathways of glutamine metabolism through metabolic flux analysis using L-Glutamine-[4-13C]. Researchers incorporate this isotope into cell cultures to precisely trace carbon flow across metabolic networks, employing advanced techniques like mass spectrometry and NMR spectroscopy. This approach provides detailed insights into cellular metabolism under different perturbations, unraveling the complexities of metabolic flux dynamics.

Cancer Research: Uncover the nuances of tumor metabolism with L-Glutamine-[4-13C] in cancer research. Tumor cells exhibit heightened glutamine uptake and utilization, and this isotope facilitates tracking glutamine’s contributions to biosynthetic processes and energy production in cancer cells. By studying these metabolic alterations, researchers pave the way for targeted therapies that capitalize on the vulnerabilities unique to tumor metabolism.

Nutritional Studies: Investigate the multifaceted role of glutamine in health and disease through nutritional studies utilizing L-Glutamine-[4-13C]. By tracing the fate of this labeled amino acid in various tissues, scientists gain valuable insights into its absorption, utilization, and conversion into metabolites. This knowledge sheds light on the nutritional needs and metabolic implications of glutamine supplementation, enriching our understanding of this essential amino acid’s physiological impacts.

Neuroscience Research: Embark on a journey into the intricate world of brain metabolism and function using L-Glutamine-[4-13C] in neuroscience research. Glutamine serves as a crucial precursor for neurotransmitters like glutamate and GABA, influencing neuronal communication and signaling. With this isotope, researchers can unravel the dynamic interplay between neurotransmitter cycling and energy metabolism in brain cells, offering profound insights into brain function and the pathophysiology of neurological disorders.