Stable isotope labeling allows researchers to study metabolic pathways in vivo in a safe manner.
Stable isotope-labeled compounds are used as environmental pollutant standards for the detection of air, water, soil, sediment and food.
In addition to treating various diseases, isotopes are used for imaging, diagnosis, and newborn screening.
Small molecule compounds labeled with stable isotopes can be used as chemical reference for chemical identification, qualitative, quantitative, detection, etc. Various types of NMR solvents can be used to study the structure, reaction mechanism and reaction kinetics of compounds.
Stable isotope labeling allows researchers to study metabolic pathways in vivo in a safe manner.
Stable isotope-labeled compounds are used as environmental pollutant standards for the detection of air, water, soil, sediment and food.
General Information |
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Catalog: BLP-004331 |
CAS: 1200447-00-2 |
Molecular Formula: 13C6H15Cl15N2O2 |
Molecular Weight: 190.59 |
Chemical Structure |
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Description | L-Lysine-[13C6,15N2] Hydrochloride is the labelled analogue of L-Lysine hydrochloride, which has been used in SILAC isotopic labeling for the characterization of lysine racemase. |
Synonyms | L-Lysine-13C6,15N2 hydrochloride;L-Lysine-13C6,15N2 (hydrochloride);1200447-00-2;HY-N0470S3;CS-0379556;L-Lysine-13C6,15N2 hydrochloride, 99 atom % 13C, 99 atom % 15N, 95% (CP); |
IUPAC Name | (2S)-2,6-bis(15N)(azanyl)(1,2,3,4,5,6-13C6)hexanoic acid;hydrochloride |
Related CAS | 657-27-2 (unlabelled) |
Canonical SMILES | O=[13C](O)[13C@H]([13CH2][13CH2][13CH2][13CH2][15NH2])[15NH2].Cl |
InChI | InChI=1S/C6H14N2O2.ClH/c7-4-2-1-3-5(8)6(9)10;/h5H,1-4,7-8H2,(H,9,10);1H/t5-;/m0./s1/i1+1,2+1,3+1,4+1,5+1,6+1,7+1,8+1; |
InChI Key | BVHLGVCQOALMSV-GSMNGUNQSA-N |
Melting Point | 263-264°C (dec.) (lit.) |
Purity | 95% by HPLC; 99% atom 15N, 99% atom 13C |
Solubility | Slightly soluble in Aqueous Acid, Water |
Appearance | Solid |
Storage | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
L-Lysine-[13C6,15N2] hydrochloride, a stable isotope-labeled amino acid, finds diverse applications in scientific research. Here are key applications of L-Lysine-[13C6,15N2] hydrochloride presented with high perplexity and burstiness:
Proteomics Research: In the realm of proteomics, L-Lysine-[13C6,15N2] hydrochloride plays a pivotal role in exploring protein expression modifications and interactions. By integrating this labeled lysine into proteins, scientists conduct quantitative mass spectrometry, comparing protein abundances across distinct biological samples. This sophisticated technique, known as SILAC (Stable Isotope Labeling by Amino acids in Cell culture), is indispensable for unraveling the dynamic and functional landscape of cellular proteins.
Metabolic Flux Analysis: Within the domain of metabolic studies, L-Lysine-[13C6,15N2] hydrochloride acts as a potent tracer for tracing metabolic pathways. It enables researchers to unveil the intricate flow of carbon and nitrogen through metabolic networks, pinpointing flux alterations under diverse physiological conditions. This deep insight serves as a cornerstone for constructing metabolic models and refining biotechnological processes like microbial fermentation, driving innovation in bioengineering.
Nutritional Studies: Delving into nutritional research, L-Lysine-[13C6,15N2] hydrochloride emerges as a crucial tool for probing amino acid metabolism and dietary needs in both humans and animals. By administering this labeled compound, researchers track lysine absorption, utilization, and excretion, unearthing crucial insights into protein metabolism. This knowledge underpins the formulation of well-rounded diets and sheds light on nutritional deficiencies, fostering a holistic understanding of dietary requirements.
Pharmaceutical Development: In the arena of pharmaceuticals, this labeled lysine is harnessed for advancing pharmacokinetic and pharmacodynamic studies, elucidating drug-protein interactions. By integrating L-Lysine-[13C6,15N2] into drug formulations or therapeutic proteins, scientists monitor their distribution and metabolism within the body. These rigorous investigations are imperative for evaluating drug efficacy, safety, and optimal dosing strategies, shaping the future of precision medicine and therapeutic interventions.
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