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L-Methionine-[2-d]

General Information
Catalog: BLP-004326
CAS: 77369-58-5
Molecular Formula: C5H10DNO2S
Molecular Weight: 150.22
Chemical Structure
L-Methionine-[2-d]
Description L-Methionine-[2-d] is a labelled L-Methionine. Methionine is an α-amino acid essential for humans. Methionine plays a role in angiogenesis.
Synonyms L-Methionine D1; SILAC Amino Acid d1; H-Met-OH-d1
IUPAC Name (2S)-2-amino-2-deuterio-4-methylsulfanylbutanoic acid
Related CAS 63-68-3 (unlabelled)
Canonical SMILES CSCCC(C(=O)O)N
InChI InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1/i4D
InChI Key FFEARJCKVFRZRR-ZVRRFCHQSA-N
Melting Point 284°C (dec.)(lit.)
Purity 95% by HPLC; 98% atom D
Storage Store at -20°C

L-Methionine-[2-d], a stable isotope-labeled amino acid, serves diverse purposes in scientific research and industrial applications. Here are key applications of L-Methionine-[2-d] elucidated with a high degree of perplexity and burstiness:

Metabolic Flux Analysis: In the realm of metabolic flux analysis, L-Methionine-[2-d] emerges as a pivotal tool for probing the intricacies of methionine metabolism across diverse organisms. By diligently monitoring the incorporation of this labeled amino acid, researchers delve into metabolic pathways and flux distributions, unraveling crucial insights. This knowledge not only sheds light on disease states but also plays a vital role in refining metabolic engineering strategies, shaping the future of precision medicine.

Protein Turnover Studies: Delving into the realm of protein turnover studies, researchers harness the power of L-Methionine-[2-d] to scrutinize the rates of protein biosynthesis and degradation within cellular systems. Through the strategic integration of L-Methionine-[2-d] into proteins, scientists embark on a journey to quantify protein turnover utilizing cutting-edge mass spectrometry techniques. These studies act as a beacon, illuminating the mechanisms of protein aging and offering profound insights into how diseases impact protein homeostasis, enriching our understanding of cellular dynamics.

Stable Isotope Labeling in Mass Spectrometry: At the crossroads of quantitative proteomics and mass spectrometry, L-Methionine-[2-d] emerges as a game-changer, facilitating precise measurements of protein abundance and post-translational modifications. By seamlessly incorporating L-Methionine-[2-d] into peptides, researchers embark on a journey towards accurate quantification, peeling back the layers of complex biological systems. This methodology ushers in a new era of comparative proteomic studies, empowering scientists to dissect intricate biological networks with unprecedented accuracy, pushing the boundaries of scientific exploration.

Nutritional Studies: In the realm of nutritional research, L-Methionine-[2-d] stands as a cornerstone, enabling in-depth investigations into methionine metabolism and requirements across animal and human subjects. By meticulously analyzing its metabolic integration, researchers unlock a treasure trove of information regarding dietary needs and the profound impact of methionine on overall health. This application plays a pivotal role in optimizing dietary formulations within agriculture and clinical nutrition, shaping the future of personalized dietary interventions and enhancing overall well-being.

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