Name: L-Ornithine-[13C5,15N2] Hydrochloride
Brand: BOC Sciences
Rating: 5 (1 reviews)

General Information

Catalog: BLP-009340

CAS: 1346617-00-2

Molecular Formula: [13C]5H13Cl[15N]2O2

Molecular Weight: 175.57

Chemical Structure

Description	L-Ornithine-[13C5,15N2] Hydrochloride is the isotope form of L-Ornithine Hydrochloride, which is a non-essential amino acid for human development but is a required intermediate in arginine biosynthesis.
Synonyms	5-Amino-L-norvaline-13C5,15N2; L-(+)-Ornithine-13C5,15N2 Monohydrochloride; 2,5-Diaminopentanoic-13C5,15N2 acid hydrochloride
IUPAC Name	(2S)-2,5-bis(15N)(azanyl)(1,2,3,4,5-13C5)pentanoic acid;hydrochloride
Related CAS	3184-13-2 (unlabelled)
Canonical SMILES	C(CC(C(=O)O)N)CN.Cl
InChI	InChI=1S/C5H12N2O2.ClH/c6-3-1-2-4(7)5(8)9;/h4H,1-3,6-7H2,(H,8,9);1H/t4-;/m0./s1/i1+1,2+1,3+1,4+1,5+1,6+1,7+1;
InChI Key	GGTYBZJRPHEQDG-DSNAFDLYSA-N
Purity	98% by HPLC; 99% atom 13C, 99% atom 15N

L-Ornithine-[13C5,15N2] Hydrochloride, a stable isotope-labeled compound widely used in metabolic and physiological studies, offers diverse applications in scientific research. Here are the key applications:

Metabolic Flux Analysis: Researchers harness L-Ornithine-[13C5,15N2] Hydrochloride in metabolic flux analysis to trace the intricate movements and conversions of ornithine within diverse metabolic pathways. By incorporating this labeled compound, scientists can accurately quantify the pace of metabolic reactions and fluxes, shedding light on the dynamic interplay of metabolic networks and pinpointing critical bottlenecks in metabolic processes.

Hyperammonemia Research: In the realm of hyperammonemia research, L-Ornithine-[13C5,15N2] Hydrochloride emerges as a vital tool for comprehending and combating the elevated levels of ammonia in the blood characterizing this condition. The labeled compound facilitates the evaluation of treatment efficacy in enhancing the urea cycle and mitigating ammonia toxicity, laying the groundwork for therapeutic strategies targeting urea cycle disorders and liver ailments.

Nutritional Studies: Delving into nutritional investigations, L-Ornithine-[13C5,15N2] Hydrochloride plays a pivotal role in exploring protein metabolism and amino acid kinetics in both human and animal subjects. By tracing the incorporation of labeled ornithine into proteins and various metabolites, scientists can assess the impact of dietary interventions on amino acid utilization and metabolic well-being. This methodology fuels the refinement of nutritional guidelines and therapeutic dietary regimens.

Pharmaceutical Development: At the forefront of pharmaceutical innovation, L-Ornithine-[13C5,15N2] Hydrochloride serves as a cornerstone in the development and evaluation of novel drugs targeting the urea cycle and related pathways. The labeled compound allows for meticulous monitoring of drug effectiveness and kinetics in preclinical and clinical settings, furnishing crucial data for drug formulation, dosage optimization, and deepening the understanding of the pharmacodynamic and pharmacokinetic properties of emerging treatments.