L-Ornithine-[5-13C,4,4,5,5-d4] hydrochloride

L-Ornithine-[5-13C,4,4,5,5-d4] hydrochloride is a stable isotope-labeled compound used in various research and diagnostic applications. Here are some key applications of L-Ornithine-[5-13C,4,4,5,5-d4] hydrochloride:

Metabolic Flux Analysis: This labeled form of L-Ornithine is extensively used in metabolic flux analysis to trace and quantify the flow of carbon and nitrogen through metabolic pathways. By incorporating L-Ornithine-[5-13C,4,4,5,5-d4] into cellular systems, researchers can study the dynamics of the urea cycle and other interconnected metabolic networks. This information is crucial for understanding metabolic disorders and optimizing metabolic engineering processes.

Nutritional Studies: L-Ornithine-[5-13C,4,4,5,5-d4] hydrochloride is used in nutritional and clinical studies to monitor amino acid metabolism and protein turnover in humans and animals. When administered, the labeled compound allows for precise measurement of metabolic rates and nutrient utilization. This aids in the development of dietary interventions and the assessment of nutritional status in various populations.

Pharmacokinetics: In pharmacokinetics research, isotopically labeled L-Ornithine is valuable for studying the absorption, distribution, metabolism, and excretion of ornithine-containing drugs and supplements. By tracking the labeled compound, scientists can obtain detailed pharmacokinetic profiles and improve drug formulation strategies. This helps in optimizing dosage regimens and understanding drug interactions.

Enzymatic Function Studies: L-Ornithine-[5-13C,4,4,5,5-d4] hydrochloride is utilized to investigate the catalytic mechanisms and substrate specificity of enzymes involved in ornithine metabolism. By providing a distinct isotopic signature, the labeled compound allows for precise monitoring of enzymatic reactions and intermediate formation. This knowledge is essential for enzyme engineering and the design of enzyme inhibitors for therapeutic purposes.