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L-Tyrosine-[1,2,3-13C3]

General Information
Catalog: BLP-009837
CAS: 286460-83-1
Molecular Formula: C6[13C]3H11NO3
Molecular Weight: 184.17
Chemical Structure
L-Tyrosine-[1,2,3-13C3]
Description L-Tyrosine-[1,2,3-13C3] is a labelled L-Tyrosine. Tyrosine is a non-essential amino acid synthesized from phenylalanine. It is the precursor of some neurotransmitters.
Synonyms L-4-Hydroxyphenylalanine-1,2,3-13C3
IUPAC Name (2S)-2-amino-3-(4-hydroxyphenyl)(1,2,3-13C3)propanoic acid
Related CAS 60-18-4 (unlabelled)
Canonical SMILES C1=CC(=CC=C1CC(C(=O)O)N)O
InChI InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1/i5+1,8+1,9+1
InChI Key OUYCCCASQSFEME-RGZNPSMASA-N
Melting Point 300°C (dec.)(lit.)
Purity 95% by HPLC; 99% atom 13C

L-Tyrosine-[1,2,3-13C3], an isotopically labeled amino acid, finds diverse applications in the biosciences. Here are key applications of L-Tyrosine-[1,2,3-13C3] presented with a high degree of perplexity and burstiness:

Metabolic Flux Analysis: Widely utilized in metabolic flux analysis, L-Tyrosine-[1,2,3-13C3] plays a pivotal role in tracing and quantifying metabolic pathways. By integrating this labeled amino acid into cellular systems, researchers unravel the distribution and transformation of carbon atoms within intricate metabolic networks. This approach offers profound insights into cellular metabolism, guiding advancements in metabolic engineering and disease research.

Protein Structure Studies: In the realms of NMR spectroscopy and mass spectrometry, L-Tyrosine-[1,2,3-13C3] emerges as a prized precursor for probing protein structure and dynamics. Through protein labeling with this isotope, scientists delve into protein folding, interactions, and conformational changes. This knowledge is essential for deciphering protein functionality and designing therapeutic interventions targeting specific proteins.

Neurotransmitter Research: Delving into the biosynthesis of crucial neurotransmitters like dopamine and norepinephrine, L-Tyrosine-[1,2,3-13C3] sheds light on the enzymatic pathways within neuronal cells. By tracking the labeled tyrosine through these pathways, researchers deepen their comprehension of neurotransmitter metabolism and regulation. Insights gained from this research may drive innovations in treatments for neurological disorders.

Nutritional Studies: In the realm of nutritional research, L-Tyrosine-[1,2,3-13C3] serves as a valuable tool for investigating amino acid metabolism and protein turnover in organisms. By assessing the incorporation and utilization of this labeled tyrosine across various tissues, scientists glean information on dietary amino acid requirements and metabolic processes. These studies contribute to the development of optimized nutritional strategies and aid in the understanding of disorders linked to amino acid metabolism.

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