Name: L-Tyrosine-[phenol-17O]
Brand: BOC Sciences
Rating: 5 (1 reviews)

General Information

Catalog: BLP-009551

Molecular Formula: C9H11NO2[17O]

Molecular Weight: 182.19

Chemical Structure

Description	L-Tyrosine-[phenol-17O], a 17O labelled analogue of L-Tyrosine. L-Tyrosine is biologically converted from L-phenylalanine and in turn is converted to L-DOPA and further converted into the neurotransmitters: dopamine, norepinephrine, and epinephrine.
Related CAS	60-18-4 (unlabelled)
InChI	InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1/i5D2,11+1
InChI Key	OUYCCCASQSFEME-OEZXKANASA-N
Purity	98% by CP; 40% atom 17O
Appearance	White Solid

L-Tyrosine-[phenol-17O], an isotopically labeled amino acid, finds applications in a wide range of advanced research endeavors. Here are the key applications of L-Tyrosine-[phenol-17O]:

Metabolic Flux Analysis: Delving into the intricate pathways of amino acid metabolism, L-Tyrosine-[phenol-17O] is a pivotal tool in metabolic flux analysis. By introducing the stable oxygen isotope, researchers can meticulously track the fate of tyrosine within cells, shedding light on the nuances of amino acid processing and utilization. This technique offers profound insights into the labyrinthine networks of cellular metabolism.

Protein Structure and Function Studies: In the realm of proteomics, L-Tyrosine-[phenol-17O] plays a crucial role in unraveling the mysteries of protein structure and function. Through the incorporation of isotope-labeled tyrosine into proteins, scientists embark on detailed explorations utilizing cutting-edge techniques like nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry. These investigations empower researchers to decipher intricate protein conformational changes and molecular interactions, opening new vistas in the study of proteins.

Enzyme Mechanism Investigation: Unlocking the secrets of enzyme catalysis and reaction mechanisms, L-Tyrosine-[phenol-17O] offers a window into the world of biochemical transformations. Researchers leverage this isotopically labeled amino acid to scrutinize the intricate interactions between enzymes and tyrosine substrates. By unraveling these mechanisms, novel insights emerge, paving the way for the development of more potent enzyme modulators with therapeutic potential.

Neurotransmitter Dynamics: Serving as a cornerstone in the biosynthesis of crucial neurotransmitters like dopamine and norepinephrine, L-Tyrosine-[phenol-17O] takes center stage in understanding neurotransmitter dynamics. By employing this labeled compound, researchers can meticulously trace the synthesis and degradation pathways of these vital neurotransmitters in neurological investigations. This knowledge holds immense significance in the exploration of neurological disorders, such as Parkinson's disease, offering a gateway to novel therapeutic avenues.