L-glucose-[UL-13C6]

L-glucose-[UL-13C6], a uniformly labeled isotopic form of glucose, finds diverse applications in scientific research. Explore the key applications of L-glucose-[UL-13C6]:

Metabolic Flux Analysis: In the realm of metabolic flux analysis, L-glucose-[UL-13C6] emerges as a pivotal tool for unraveling carbon pathways within cellular metabolism. By integrating this labeled glucose into cellular systems, researchers delve into dynamic changes in metabolite concentrations and fluxes. This intricate exploration offers profound insights into the regulation of metabolic networks and aids in pinpointing bottlenecks residing within metabolic pathways.

NMR Spectroscopy: Within the domain of nuclear magnetic resonance (NMR) spectroscopy, L-glucose-[UL-13C6] assumes a crucial role as a tracer of high significance. Its uniform labeling with carbon-13 facilitates detailed structural and functional analysis of metabolites present in complex biological mixtures. This methodological approach proves particularly beneficial for discerning and quantifying intracellular metabolites, thereby shedding light on intricate metabolic mechanisms at play.

Mass Spectrometry: In the landscape of mass spectrometry-based investigations, L-glucose-[UL-13C6] serves as an invaluable internal standard or tracer for quantitative analysis. This application aids in enhancing the precision of mass spectrometry measurements by rectifying variations in sample preparation and instrument response. Such meticulous correction is indispensable for accurate metabolic profiling and the discovery of potential biomarkers, advancing the frontier of metabolic research.

Cancer Research: Within the dynamic field of cancer research, L-glucose-[UL-13C6] emerges as a pivotal player in unveiling the altered metabolic pathways residing within tumor cells. By tracing the journey of labeled glucose through glycolysis and other metabolic avenues, scientists gain deep insights into the metabolic adaptations and dependencies exhibited by cancer cells. This exploration serves as a cornerstone in comprehending cancer metabolism intricacies and propels the development of targeted therapeutic interventions with precision and efficacy.