N-Acetyl-L-aspartic acid-[15N]

N-Acetyl-L-aspartic acid-[15N] is a stable isotope-labeled compound used in numerous scientific research applications due to its unique properties. Here are some key applications of N-Acetyl-L-aspartic acid-[15N]:

Neuroscience Research: N-Acetyl-L-aspartic acid (NAA) is an important metabolite in the brain, and its isotopically labeled version is used to study brain metabolism and function. By tracing NAA labeled with [15N] in neuroimaging studies, researchers can gain insights into neuronal density and integrity. This application is crucial for understanding disorders like multiple sclerosis and Alzheimer's disease.

Metabolic Pathway Tracing: In metabolic studies, N-Acetyl-L-aspartic acid-[15N] is employed to trace and elucidate metabolic pathways involving NAA. By incorporating the [15N] isotope, scientists can follow the synthesis and degradation of NAA within cells. This helps in understanding the metabolic roles of NAA and its potential impact on cell physiology.

Pharmaceutical Research: The labeled N-Acetyl-L-aspartic acid is used in the development and testing of drugs that target brain metabolism. It serves as a tracer to evaluate the efficacy and pharmacokinetics of new drugs aimed at altering NAA levels. This application aids in optimizing drug development for neurological conditions.

Magnetic Resonance Spectroscopy: N-Acetyl-L-aspartic acid-[15N] is utilized in magnetic resonance spectroscopy (MRS) for non-invasive studies of brain chemistry. The presence of the [15N] label enhances the detection and quantification of NAA in the brain. This technique provides valuable information on metabolic changes associated with various neurological disorders.