CAS 1346605-02-4 Ondansetron-[d3] Hydrochloride

General Information
Catalog: BLP-003668
CAS: 1346605-02-4
Molecular Formula: C18H17D30ClN3O
Molecular Weight: 332.84

General Information

Catalog: BLP-003668

CAS: 1346605-02-4

Molecular Formula: C18H17D30ClN3O

Molecular Weight: 332.84

Chemical Structure

Description	Ondansetron-[d3] Hydrochloride, is the labelled analogue of Ondansetron, which is a serotonin 5-HT3 receptor antagonist used mainly as an antiemetic.
Synonyms	Ondansetron-d3 Hydrochloride Salt
IUPAC Name	3-[(2-methylimidazol-1-yl)methyl]-9-(trideuteriomethyl)-2,3-dihydro-1H-carbazol-4-one;hydrochloride
Related CAS	99614-01-4 (unlabelled)
Canonical SMILES	CC1=NC=CN1CC2CCC3=C(C2=O)C4=CC=CC=C4N3C.Cl
InChI	InChI=1S/C18H19N3O.ClH/c1-12-19-9-10-21(12)11-13-7-8-16-17(18(13)22)14-5-3-4-6-15(14)20(16)2;/h3-6,9-10,13H,7-8,11H2,1-2H3;1H/i2D3;
InChI Key	MKBLHFILKIKSQM-MUTAZJQDSA-N
Boiling Point	546.0±30.0°C at 760 mmHg
Melting Point	172-174°C
Purity	98% by CP; 98% atom D
Density	1.3±0.1 g/cm3
Solubility	Soluble in DMSO, Methanol, Water
Appearance	White to Off-white Solid
Storage	Store at 2-8°C

Ondansetron-[d3] Hydrochloride, a deuterated variant of ondansetron, a medication renowned for its anti-nausea and anti-vomiting properties, has diverse applications. Here are key applications described with a high degree of perplexity and burstiness:

Pharmacokinetic Studies: Utilizing Ondansetron-[d3] Hydrochloride in pharmacokinetic studies allows researchers to delve into the intricate processes of drug absorption, distribution, metabolism, and excretion within the human body. The deuterated form, with its unique mass differential, facilitates precise tracking in mass spectrometry, making it easily discernible from its non-deuterated counterpart. This distinction is essential for optimizing dosages and comprehending drug interactions in therapeutic contexts.

Clinical Research: In the realm of clinical research, Ondansetron-[d3] Hydrochloride serves as a vital internal standard that guarantees the accuracy and dependability of analytical methodologies. By acting as a benchmark compound, it aids in quantifying ondansetron levels in biological specimens. This application plays a crucial role in validating bioanalytical assays and ensuring consistent outcomes across various research endeavors.

Antiemetic Therapy: While Ondansetron-[d3] Hydrochloride isn't used as a direct therapeutic intervention, it offers valuable insights that can elevate antiemetic treatments to new heights. Through an exploration of its pharmacokinetics, researchers can craft enhanced formulations of ondansetron that exhibit superior efficacy and reduced adverse effects.

Drug Development: Within the domain of drug development research, Ondansetron-[d3] Hydrochloride plays a pivotal role in unraveling metabolic pathways and potential drug-drug interactions. With its stable isotopic labeling, it aids in the identification and quantification of metabolites, offering a deeper understanding of ondansetron's metabolic intricacies.