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Pentanedioic-[d6] acid

General Information
Catalog: BLP-013968
CAS: 154184-99-3
Molecular Formula: C5H2D6O4
Molecular Weight: 138.15
Chemical Structure
Pentanedioic-[d6] acid
Description Pentanedioic-[d6] acid is a labelled analogue of Glutaric Acid, which is a compound useful in organic synthesis.
Synonyms Glutaric acid-d6; Glutaric-d6 Acid; 1,5-Pentanedioic acid-d6
IUPAC Name 2,2,3,3,4,4-hexadeuteriopentanedioic acid
Related CAS 110-94-1 (unlabelled)
Isomeric SMILES [2H]C([2H])(C(=O)O)C([2H])([2H])C([2H])([2H])C(=O)O
Canonical SMILES C(CC(=O)O)CC(=O)O
InChI InChI=1S/C5H8O4/c6-4(7)2-1-3-5(8)9/h1-3H2,(H,6,7)(H,8,9)/i1D2,2D2,3D2
InChI Key JFCQEDHGNNZCLN-NMFSSPJFSA-N
Melting Point 93-95°C
Purity 98 atom % D
Solubility Soluble in Chloroform (Slightly), Methanol (Slightly)
Appearance White to Off-white Solid
Storage Store at 2-8°C

Pentanedioic-[d6] acid, a deuterated variant of glutaric acid, finds diverse applications across scientific and industrial realms, lauded for its isotopic labeling attributes. Here are pivotal applications of Pentanedioic-[d6] acid presented with heightened perplexity and burstiness:

Metabolic Tracing: Delving into metabolic intricacies, Pentanedioic-[d6] acid emerges as an invaluable isotopic tracer, enabling researchers to navigate metabolic pathways and intermediates with precision. Its deuterium tag facilitates detection via mass spectrometry, offering profound insights into biochemical processes. This utility plays a pivotal role in deciphering disease mechanisms, scrutinizing metabolic dysfunctions, and unraveling cellular metabolic fluxes.

Pharmacokinetic Studies: At the forefront of pharmacokinetic exploration, Pentanedioic-[d6] acid serves as a linchpin in investigating the absorption, distribution, metabolism, and excretion (ADME) of pharmaceutical compounds. By tagging drug molecules with Pentanedioic-[d6] acid, researchers can meticulously monitor and quantify drug dynamics within biological milieus. This aids in fine-tuning dosing protocols, optimizing drug effectiveness, and bolstering safety profiles.

NMR Spectroscopy: Within the realm of NMR spectroscopy, Pentanedioic-[d6] acid assumes a dual role as a reference standard and an internal standard, facilitating quantitative analyses with finesse. Its distinctive isotopic fingerprint simplifies the analysis of intricate biological samples, offering clarity in structural elucidation. This application proves pivotal in structural biology endeavors, aiding in the characterization of biomolecules and decoding their intricate interactions.

Environmental Studies: Pentanedioic-[d6] acid emerges as a key player in environmental research, spearheading the tracing and exploration of organic acid cycling within ecosystems. Its usage sheds light on carbon flux and nutrient circulation in soil and aquatic domains, providing crucial insights into environmental dynamics. These investigations contribute significantly to understanding environmental processes and bolstering ecosystem resilience.

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