Name: (R)-(-)-Tamsulosin-[d5] Hydrochloride
Brand: BOC Sciences
Rating: 5 (1 reviews)

General Information

Catalog: BLP-001628

Molecular Formula: C20H24D5ClN2O5S

Molecular Weight: 450

Chemical Structure

Description	One of the isotopic labelled form of (R)-(-)-Tamsulosin, which is an α1-adrenoceptor antagonist and could be used against benign prostatic hypertrophy.
Synonyms	5-[(2R)-2-[[2-(-Ethoxyphenoxy)ethyl]amino]propyl]-2-methoxybenzenesulfonamide-d5 Hydrochloride; Flomax-d5; Harnal-d5; Omnic-d5; Pradif-d5; YM 12617-1-d5; YM 617-d5; Yutanal-d5; (R)-(-)-Tamsulosin D5 Hydrochloride
IUPAC Name	(R)-5-(2-((2-(2-(ethoxy-d5)phenoxy)ethyl)amino)propyl)-2-methoxybenzenesulfonamide hydrochloride
Related CAS	1092970-47-2 (free base) 106463-17-6 (unlabelled)
Melting Point	227-229°C
Purity	>98%
Solubility	Soluble in Methanol
Appearance	White Solid
Storage	Store at -20°C

(R)-(-)-Tamsulosin-[d5] Hydrochloride, a deuterated isotopic variant of Tamsulosin, finds widespread utility in pharmaceutical and medical research. Here are the key applications of (R)-(-)-Tamsulosin-[d5] Hydrochloride:

Pharmacokinetic Studies: Delving into the intricacies of pharmacokinetics, (R)-(-)-Tamsulosin-[d5] Hydrochloride serves as a beacon for unraveling the absorption, distribution, metabolism, and excretion of Tamsulosin within the human body.

Drug Metabolism Research: Enthusiastically embraced by researchers, (R)-(-)-Tamsulosin-[d5] Hydrochloride illuminates the metabolic pathways of Tamsulosin, particularly within the liver and other vital tissues. Through insightful investigations of interactions with cytochrome P450 enzymes, utilizing deuterium-labeled compounds, a newfound understanding of drug metabolism and potential drug-drug interactions emerges, guiding the fine-tuning of drug formulations and the mitigation of adverse effects.

Bioavailability Studies: Embarking on the quest for enhanced bioavailability assessment, the deuterated rendition of Tamsulosin plays a pivotal role in discerning the bioequivalence of various Tamsulosin formulations. Embarking on clinical and preclinical journeys, researchers meticulously compare pharmacological profiles to ensure consistent therapeutic efficacy across diverse drug products, thus safeguarding that generic Tamsulosin offerings uphold the same exacting standards as their progenitors.

Analytical Method Development: Serving as the linchpin in the realm of analytical method evolution, (R)-(-)-Tamsulosin-[d5] Hydrochloride stands tall in driving the development and validation of analytical methods for precise drug quantification. Its deployment as an internal standard in high-performance liquid chromatography (HPLC) and mass spectrometry assays enhances the accuracy and precision of drug measurement, underscoring the indispensable role of reliable analytical methods in upholding pharmaceutical quality control standards.