Stable isotope-labeled compounds are used as environmental pollutant standards for the detection of air, water, soil, sediment and food.
In addition to treating various diseases, isotopes are used for imaging, diagnosis, and newborn screening.
Small molecule compounds labeled with stable isotopes can be used as chemical reference for chemical identification, qualitative, quantitative, detection, etc. Various types of NMR solvents can be used to study the structure, reaction mechanism and reaction kinetics of compounds.
Stable isotope labeling allows researchers to study metabolic pathways in vivo in a safe manner.
General Information |
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Catalog: BLP-004019 |
CAS: 1216451-53-4 |
Molecular Formula: C15H9D4NO3 |
Molecular Weight: 259.29 |
Chemical Structure |
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Description | Labelled rac Ketorolac. Ketorolac, a non-selective COX inhibitor, is a non-steroidal anti-inflammatory drug. It shows inhibition of eicosanoid formation in HEL cells (COX-1) and LPS-stimulated Mono Mac 6 cells (COX-2), but does not significantly inhibit NO accumulation in supernatants of LPS-stimulated RAW 264.7 cells. It significantly inhibits thymidine incorporation of human osteoblasts (hOBs) upon 24 hours treatment in a dose-dependent manner, and inhibits proliferation and arrests cell cycle at G0/G1 phase in hOBs. |
Synonyms | 5-Benzoyl-2,3-dihydro-1H-(pyrrolizine-d4)-1-carboxylic Acid; (+/-)-Ketorolac-d4; Ketorolac-d4; RS 37619-d4 |
IUPAC Name | 5-benzoyl-2,2,3,3-tetradeuterio-1H-pyrrolizine-1-carboxylic acid |
Related CAS | 74103-06-3 (unlabelled) |
Isomeric SMILES | [2H]C1(C(C2=CC=C(N2C1([2H])[2H])C(=O)C3=CC=CC=C3)C(=O)O)[2H] |
Canonical SMILES | C1CN2C(=CC=C2C(=O)C3=CC=CC=C3)C1C(=O)O |
InChI | InChI=1S/C15H13NO3/c17-14(10-4-2-1-3-5-10)13-7-6-12-11(15(18)19)8-9-16(12)13/h1-7,11H,8-9H2,(H,18,19)/i8D2,9D2 |
InChI Key | OZWKMVRBQXNZKK-LZMSFWOYSA-N |
Melting Point | 149-151°C |
Purity | >98% |
Solubility | Soluble in Chloroform, Methanol |
Appearance | Beige Solid |
Storage | Store at-20°C |
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