rac Ketorolac-[d4]

General Information
Catalog: BLP-004019
CAS: 1216451-53-4
Molecular Formula: C15H9D4NO3
Molecular Weight: 259.29
Related CAS: 74103-06-3 (unlabelled)
Description Labelled rac Ketorolac. Ketorolac, a non-selective COX inhibitor, is a non-steroidal anti-inflammatory drug. It shows inhibition of eicosanoid formation in HEL cells (COX-1) and LPS-stimulated Mono Mac 6 cells (COX-2), but does not significantly inhibit NO accumulation in supernatants of LPS-stimulated RAW 264.7 cells. It significantly inhibits thymidine incorporation of human osteoblasts (hOBs) upon 24 hours treatment in a dose-dependent manner, and inhibits proliferation and arrests cell cycle at G0/G1 phase in hOBs.
Synonyms 5-Benzoyl-2,3-dihydro-1H-(pyrrolizine-d4)-1-carboxylic Acid; (+/-)-Ketorolac-d4; Ketorolac-d4; RS 37619-d4
IUPAC Name 5-benzoyl-2,2,3,3-tetradeuterio-1H-pyrrolizine-1-carboxylic acid
Canonical SMILES C1CN2C(=CC=C2C(=O)C3=CC=CC=C3)C1C(=O)O
InChI InChI=1S/C15H13NO3/c17-14(10-4-2-1-3-5-10)13-7-6-12-11(15(18)19)8-9-16(12)13/h1-7,11H,8-9H2,(H,18,19)/i8D2,9D2
Melting Point 149-151°C
Purity >98%
Solubility Soluble in Chloroform, Methanol
Appearance Beige Solid
Storage Store at-20°C

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