Name: Rifapentine-[d9]
Brand: BOC Sciences
Rating: 5 (1 reviews)

General Information

Catalog: BLP-004138

CAS: 2738376-69-5

Molecular Formula: C47H55D9N4O12

Molecular Weight: 886.10

Chemical Structure

Description	Rifapentine-[d9] is an isotope analogue of Rifapentine. Rifapentine (Priftin) is a semi-synthetic antibiotic compound used in the treatment of tuberculosis and it inhibits DNA-dependent RNA polymerases and is effective against Mycobacterium species, including M. tuberculosis, as well as experimental infections caused by S. aureus, S. pyogenes group A, S. pneumoniae, and K. pneumoniae.
Synonyms	Rifapentine-d9; 3-[[(4-cyclopentyl-1-piperazinyl)imino]methyl]-rifamycin-d9; Cyclopentylrifampicin-d9
Related CAS	61379-65-5 (unlabelled)
Canonical SMILES	OC(C1=C(C2=O)C(O[C@@]2(O/C=C/[C@@H]([C@H]([C@@]([C@@H]3C)([H])OC(C)=O)C)OC)C)=C(C)C(O)=C1C(O)=C4NC(/C(C)=C\C=C\[C@@H]([C@@H]([C@@H](C)[C@H]3O)O)C)=O)=C4/C=N/N5CCN(C6([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C6([2H])[2H])CC5
InChI Key	WDZCUPBHRAEYDL-ZZSWSMFNSA-N
Purity	>99%
Solubility	Soluble in Acetonitrile; DMSO; Methanol
Storage	Store at 2-8°C

Rifapentine-[d9] is a deuterated analog of rifapentine used primarily in tuberculosis research and drug development. Here are some key applications of Rifapentine-[d9]:

Pharmacokinetic Studies: Rifapentine-[d9] is employed in pharmacokinetic studies to track the absorption, distribution, metabolism, and excretion of rifapentine in the body. By using the deuterated form, researchers can distinguish it from the natural isotopic form in biological samples. This is essential for precise measurement of drug concentrations and understanding the drug's behavior in different tissues.

Drug Interaction Research: Rifapentine-[d9] is used to assess potential drug-drug interactions during the development of tuberculosis treatment regimens. Its unique isotopic labeling allows researchers to determine interactions without interference from endogenous compounds.

Metabolite Identification: The use of Rifapentine-[d9] aids in identifying and quantifying metabolites of rifapentine in biological systems. Its deuterium label provides a clear signature distinguishing it from other metabolites. This information is crucial for understanding the metabolic pathways and potential side effects of the drug.

Stable Isotope Labeling: Rifapentine-[d9] is valuable in studies requiring stable isotope labeling for more accurate mass spectrometric analysis. It enables precise quantification in complex biological matrices such as blood or tissue samples. This application is vital in bioanalytical methods development and therapeutic drug monitoring.