Sacubitril Calcium-[13C4]

General Information
Catalog: BLP-004184
Molecular Formula: C20[13C]4H28NO5.1/2Ca
Molecular Weight: 434.50
Related CAS: 1369773-39-6 (unlabelled) 149709-62-6 (unlabelled free acid)
Description Labelled Sacubitril. Sacubitril, also known as AHU377 or LCZ696, is an angiotensin receptor neprilysin inhibitor being studied for use in combination with valsartan for heart failure. Sacubitril is a prodrug that is activated to LBQ657 by de-ethylation via esterases. LBQ657 inhibits the enzyme neprilysin, which is responsible for the degradation of atrial and brain natriuretic peptide, two blood pressure lowering peptides that work mainly by reducing blood volume.
Synonyms [S-(R*,S*)]-[1,1'-Biphenyl]-4-pentanoic Acid,γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl-Ethyl Ester-13C4 Calcium
Canonical SMILES CCOC(=O)C(C)CC(CC1=CC=C(C=C1)C2=CC=CC=C2)NC(=O)CCC(=O)O.[Ca]
InChI InChI=1S/C24H29NO5.Ca/c1-3-30-24(29)17(2)15-21(25-22(26)13-14-23(27)28)16-18-9-11-20(12-10-18)19-7-5-4-6-8-19;/h4-12,17,21H,3,13-16H2,1-2H3,(H,25,26)(H,27,28);/t17-,21+;/m1./s1/i13+1,14+1,22+1,23+1;
InChI Key SLERTBUHPREHKD-XIKWNFOHSA-N
Purity 99% by HPLC; 99% atom 13C
Appearance Off-white Solid

Related Products

Online Inquiry


  • Verification code

USA

Europe

Share

Interested in our Service & Products?
Need detailed information?



Inquiry Basket